ZFIN ID: ZDB-GENE-011205-10
Gene Name: NADH dehydrogenase 4, mitochondrial
Gene Symbol: mt-nd4    Nomenclature History

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Previous Names: mtnd4 (1), ND4 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: MT Mapping Details/Browsers
Description: Predicted to have ubiquinone binding activity. Predicted to be involved in aerobic respiration and electron transport coupled proton transport. Predicted to localize to mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; Parkinson's disease; macular degeneration; and schizophrenia. Orthologous to human MT-ND4 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000063917 (2)
GENE EXPRESSION
All Expression Data: Fig. 3 from Sabharwal et al., 2018
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH mt-nd4 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH mt-nd4 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process ATP synthesis coupled electron transport (more)
Cellular Component integral component of membrane (more)
Molecular Function NADH dehydrogenase (ubiquinone) activity (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mt-nd4 No data available
MARKER RELATIONSHIPS No data available
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
Genomic GenBank:AC024175 (1) 16596 nt
Polypeptide UniProtKB:Q9MIY1 (1) 460 aa
Sequence Information (all 3)
ORTHOLOGY for mt-nd4 ( Chr: MT )
CITATIONS (24)