ZFIN ID: ZDB-GENE-011128-7
Gene Name: guanylate cyclase 2F, retinal
Gene Symbol: gucy2f    Nomenclature History

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Previous Names: gc1, RETGC-1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Exhibits guanylate cyclase activity. Involved in photoreceptor cell outer segment organization and visual perception. Predicted to localize to plasma membrane. Is expressed in olfactory epithelium; olfactory receptor cell; retina; and retinal outer nuclear layer. Used to study Leber congenital amaurosis. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 1; choroidal sclerosis; cone-rod dystrophy 6; congenital stationary night blindness; and retinitis pigmentosa. Orthologous to human GUCY2D (guanylate cyclase 2D, retinal).
Genome Resources: Alliance (1),  Gene:140424 (1),  Ensembl(GRCz11):ENSDARG00000025504 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22668 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35912 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42568 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gucy2f N/A 1
    MO2-gucy2f N/A 1
    DISEASE ASSOCIATED WITH gucy2f HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    choroidal sclerosis Alliance ?Choroidal dystrophy, central areolar 1 215500
    cone-rod dystrophy 6 Alliance Cone-rod dystrophy 6 601777
    Leber congenital amaurosis 1 Alliance Leber congenital amaurosis 1 204000
    Night blindness, congenital stationary, type 1I 618555
    DISEASE ASSOCIATED WITH gucy2f VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Leber congenital amaurosis WT + MO2-gucy2f standard conditions Stiebel-Kalish et al., 2012
    WT + MO1-gucy2f standard conditions Stiebel-Kalish et al., 2012
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process photoreceptor cell outer segment organization (more)
    Cellular Component integral component of membrane (more)
    Molecular Function guanylate cyclase activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gucy2f-202 (1)    Ensembl 4614
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gucy2f No data available
    MARKER RELATIONSHIPS
    gucy2f Contained in: [BAC] DKEY-52L18 (1) (order this)
    gucy2f Encodes: [cDNA] MGC:194231 (1), MGC:194253 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131864 (1) 3324 nt
    Genomic GenBank:BX537138 (1) 144274 nt
    Select Tool
    Polypeptide UniProtKB:B3DHF2 (1) 1107 aa
    Sequence Information (all 25)
    ORTHOLOGY for gucy2f ( Chr: 15 )
    CITATIONS (26)