ZFIN ID: ZDB-GENE-011128-5
Gene Name: guanylate cyclase activator 1A
Gene Symbol: guca1a    Nomenclature History

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Previous Name: gcap1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Exhibits calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Is expressed in eye and retina. Human ortholog(s) of this gene implicated in cone-rod dystrophy 14. Orthologous to human GUCA1A (guanylate cyclase activator 1A).
Genome Resources: Alliance (1),  Gene:140430 (1),  Ensembl(GRCz11):ENSDARG00000010454 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 5 publications
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20274 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH guca1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cone-rod dystrophy 14 Alliance Cone dystrophy-3 602093
    Cone-rod dystrophy 14 602093
    DISEASE ASSOCIATED WITH guca1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Molecular Function calcium ion binding (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA guca1a-201 (1)    Ensembl 2310
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM guca1a No data available
    MARKER RELATIONSHIPS
    guca1a Contained in: [BAC] DKEY-9A20 (1) (order this)
    guca1a Encodes: [cDNA] MGC:73169 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131870 (1) 1575 nt
    Genomic GenBank:BX537162 (1) 223816 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q1LWS5 (1) 189 aa
    Sequence Information (all 15)
    ORTHOLOGY for guca1a ( Chr: 4 )
    CITATIONS (26)