ZFIN ID: ZDB-GENE-011101-2
Gene Name: DCC netrin 1 receptor
Gene Symbol: dcc    Nomenclature History

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Previous Names: spaced out, spo, zdcc (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits netrin receptor activity involved in chemoattraction. Involved in generation of neurons. Predicted to localize to integral component of membrane. Is expressed in several structures, including brain; neural tube; pleuroperitoneal region; posterior neural rod; and primary motor neurons. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Orthologous to human DCC (DCC netrin 1 receptor).
Genome Resources: Alliance (1),  Gene:569360 (1),  Ensembl(GRCz11):ENSDARG00000104282 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12693 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13121 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16961 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20326 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31409 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tm272b Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ts239 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • zm130198Tg Transgenic Insertion Unknown Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dcc N/A 10
    MO2-dcc N/A 6
    MO3-dcc N/A 2
    DISEASE ASSOCIATED WITH dcc HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    colorectal cancer Alliance Colorectal cancer, somatic 114500
    esophageal cancer Alliance Esophageal carcinoma, somatic 133239
    Gaze palsy, familial horizontal, with progressive scoliosis, 2 617542
    Mirror movements 1 and/or agenesis of the corpus callosum 157600
    DISEASE ASSOCIATED WITH dcc VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior axon guidance (more)
    Cellular Component integral component of membrane (more)
    Molecular Function netrin receptor activity involved in chemoattraction (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dcc
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(10xUAS:dcc,myl7:EGFP) myl7 dccEGFP Danio rerio 1 2
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001034985 (1) 4266 nt
    Genomic GenBank:CABZ01088906 (1) 22627 nt
    Polypeptide UniProtKB:Q49BB0 (1) 1421 aa
    Sequence Information (all 39)
    ORTHOLOGY for dcc ( Chr: 5 )
    CITATIONS (41)