Gene

dcc

ID
ZDB-GENE-011101-2
Name
DCC netrin 1 receptor
Symbol
dcc Nomenclature History
Previous Names
  • spaced out
  • spo
  • zdcc (1)
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Exhibits netrin receptor activity involved in chemoattraction. Involved in generation of neurons. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in colorectal cancer; congenital mirror movement disorder; esophageal cancer; and esophagus squamous cell carcinoma. Is expressed in several structures, including brain; neural tube; pleuroperitoneal region; posterior neural rod; and primary motor neurons. Orthologous to human DCC (DCC netrin 1 receptor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
21 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
20 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dcc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
colorectal cancer Alliance Colorectal cancer, somatic 114500
esophageal cancer Alliance Esophageal carcinoma, somatic 133239
Gaze palsy, familial horizontal, with progressive scoliosis, 2 617542
Mirror movements 1 and/or agenesis of the corpus callosum 157600
Associated With dcc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Domain IPR010560 Neogenin, C-terminal
Domain IPR013098 Immunoglobulin I-set
Family IPR009138 Neural cell adhesion
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Neogenin, C-terminal Neural cell adhesion
UniProtKB:A0A0G2KXQ3 757
UniProtKB:A0A0B5JKA2 1069
UniProtKB:Q49BB0 1421
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations