Gene

adh5

ID
ZDB-GENE-011003-1
Name
alcohol dehydrogenase 5
Symbol
adh5 Nomenclature History
Previous Names
  • ADH3 (1)
  • fb60b11
  • gsnor (1)
  • wu:fb60b11
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in formaldehyde catabolic process. Predicted to localize to cytosol. Is expressed in several structures, including blastodisc; central nervous system; digestive system; pleuroperitoneal region; and trunk. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Cox et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adh5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
AMED syndrome, digenic 619151
Associated With adh5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
Domain IPR013149 Alcohol dehydrogenase-like, C-terminal
Domain IPR013154 Alcohol dehydrogenase-like, N-terminal
Domain IPR020843 Polyketide synthase, enoylreductase domain
Family IPR014183 Alcohol dehydrogenase class III
Homologous_superfamily IPR011032 GroES-like superfamily
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length Alcohol dehydrogenase class III Alcohol dehydrogenase-like, C-terminal Alcohol dehydrogenase-like, N-terminal Alcohol dehydrogenase, zinc-type, conserved site GroES-like superfamily NAD(P)-binding domain superfamily Polyketide synthase, enoylreductase domain
UniProtKB:Q6NXA6 376
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA adh5-201 (1) Havana 1325 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations