Gene

ache

ID
ZDB-GENE-010906-1
Name
acetylcholinesterase
Symbol
ache Nomenclature History
Previous Names
  • zgc:92550
  • ziehharmonika (1)
  • zim (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Exhibits acetylcholinesterase activity. Involved in several processes, including acetylcholine catabolic process; cellular response to methanol; and response to amphetamine. Predicted to localize to extracellular region; plasma membrane; and synapse. Is expressed in several structures, including female organism; male organism; myotome; nervous system; and neural tube. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Orthologous to human ACHE (acetylcholinesterase (Cartwright blood group)).
Genome Resources
Note
None
Expression
All Expression Data
20 figures from 13 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
22 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ache Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
[Blood group, Yt system] 112100
Associated With ache Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR019826 Carboxylesterase type B, active site
Conserved_site IPR019819 Carboxylesterase type B, conserved site
Domain IPR002018 Carboxylesterase, type B
Domain IPR014788 Acetylcholinesterase, tetramerisation domain
Family IPR000997 Cholinesterase
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Domain Details Per Protein
Protein Length Acetylcholinesterase, tetramerisation domain Alpha/Beta hydrolase fold Carboxylesterase, type B Carboxylesterase type B, active site Carboxylesterase type B, conserved site Cholinesterase
UniProtKB:Q6DHA5 215
UniProtKB:Q9DDE3 634
UniProtKB:B3DKL4 634
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations