ZFIN ID: ZDB-GENE-010906-1
Gene Name: acetylcholinesterase
Gene Symbol: ache    Nomenclature History

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Previous Names: zgc:92550, ziehharmonika (1), zim (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits acetylcholinesterase activity. Involved in several processes, including acetylcholine catabolic process; cellular response to methanol; and response to amphetamine. Predicted to localize to extracellular region; plasma membrane; and synapse. Is expressed in several structures, including female organism; male organism; myotome; nervous system; and neural tube. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Orthologous to human ACHE (acetylcholinesterase (Cartwright blood group)).
Genome Resources: Alliance (1),  Gene:114549 (1),  Ensembl(GRCz11):ENSDARG00000031796 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31572 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40891 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sb55 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tf222a Point Mutation Unknown Missense
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tm205 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tm206 Unknown Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ache N/A 1
    DISEASE ASSOCIATED WITH ache HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    [Blood group, Yt system] 112100
    DISEASE ASSOCIATED WITH ache VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process acetylcholine catabolic process (more)
    Cellular Component cell junction (more)
    Molecular Function acetylcholinesterase activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ache-201 (1)    Ensembl 4795
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ache
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(Cca.Actb:YFP,5xUAS:ache) acheYFP Cyprinus carpioDanio rerio 1 2
    MARKER RELATIONSHIPS
    ache Contained in: [BAC] CH211-153N19 (1), CH211-196F2 (1)
    ache Encodes: [EST] eu3 (1)
    [cDNA] MGC:92550 (1), MGC:195318 (1), MGC:195325 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131846 (1) 2556 nt
    Genomic GenBank:BX470232 (1) 194721 nt
    Select Tool
    Polypeptide UniProtKB:B3DKL4 (1) 634 aa
    Sequence Information (all 23)
    ORTHOLOGY for ache ( Chr: 7 )
    CITATIONS (98)