Gene

ache

ID

ZDB-GENE-010906-1

Name

acetylcholinesterase (Yt blood group)

Symbol

ache Nomenclature History

Previous Names

zgc:92550
ziehharmonika (1)
zim (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Exhibits acetylcholinesterase activity. Involved in several processes, including acetylcholine catabolic process; cellular response to methanol; and response to amphetamine. Predicted to localize to several cellular components, including cell junction; extracellular region; and synapse. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Is expressed in several structures, including female organism; male organism; myotome; nervous system; and neural tube. Orthologous to human ACHE (acetylcholinesterase (Cartwright blood group)).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

29 figures from 19 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu3 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 23 figures from 10 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ache Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		[Blood group, Yt system]	112100

Associated With ache Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR019826	Carboxylesterase type B, active site
Conserved_site	IPR019819	Carboxylesterase type B, conserved site
Domain	IPR002018	Carboxylesterase, type B
Domain	IPR014788	Acetylcholinesterase, tetramerisation domain
Family	IPR000997	Cholinesterase
Family	IPR050654	Acetylcholinesterase-related enzymes
Homologous_superfamily	IPR029058	Alpha/Beta hydrolase fold