Gene
dlg1a
- ID
- ZDB-GENE-010724-8
- Name
- discs large MAGUK scaffold protein 1a
- Symbol
- dlg1a Nomenclature History
- Previous Names
-
- dlg1
- SAP-97A (1)
- wu:fc34d02
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have phosphatase binding activity and protein kinase binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; endothelial cell proliferation; and establishment or maintenance of epithelial cell apical/basal polarity. Predicted to colocalize with ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Is expressed in nervous system; neural crest; neural tube; pigment cell; and trigeminal placode. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55810 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020590 | Guanylate kinase, conserved site |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR004172 | L27 domain |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Domain | IPR015143 | L27-1 |
| Domain | IPR019583 | Disks large homolog 1-4, PDZ-associated domain |
| Domain | IPR019590 | Disks large homologue 1, N-terminal PEST domain |
| Family | IPR016313 | Disks large 1-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036892 | L27 domain superfamily |
Domain Details Per Protein
| Protein | Length | Disks large 1-like | Disks large homolog 1-4, PDZ-associated domain | Disks large homologue 1, N-terminal PEST domain | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | L27-1 | L27 domain | L27 domain superfamily | PDZ domain | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BD79
|
898 | ||||||||||||||
|
UniProtKB:A0A8M3ATC7
|
910 | ||||||||||||||
|
UniProtKB:A0A8M2BDF3
|
860 | ||||||||||||||
|
UniProtKB:A0A8M2BD83
|
338 | ||||||||||||||
|
UniProtKB:A0A8M2BD84
|
806 | ||||||||||||||
|
UniProtKB:A0A8M2BDA2
|
935 | ||||||||||||||
|
UniProtKB:A0A8M9PLT3
|
760 | ||||||||||||||
|
UniProtKB:A0A8M3B3F8
|
899 | ||||||||||||||
|
UniProtKB:A0A8M2BDE8
|
934 | ||||||||||||||
|
UniProtKB:A0A8M9PZE5
|
713 | ||||||||||||||
|
UniProtKB:A0A8M2BDA9
|
896 | ||||||||||||||
|
UniProtKB:A0A8M2BD86
|
883 | ||||||||||||||
|
UniProtKB:A0A8M2BD78
|
934 | ||||||||||||||
|
UniProtKB:A0A8M2BDF6
|
363 | ||||||||||||||
|
UniProtKB:A0A8M9QF49
|
835 | ||||||||||||||
|
UniProtKB:A0A8M9QA35
|
824 | ||||||||||||||
|
UniProtKB:A0A8M9Q5X6
|
836 | ||||||||||||||
|
UniProtKB:A0A8M2BD80
|
860 | ||||||||||||||
|
UniProtKB:A0A8M2BD88
|
737 | ||||||||||||||
|
UniProtKB:A0A8M9PZE0
|
859 | ||||||||||||||
|
UniProtKB:A0A8M2BDB9
|
781 | ||||||||||||||
|
UniProtKB:A0A8M3B0G8
|
933 | ||||||||||||||
|
UniProtKB:Q5PYH6
|
873 | ||||||||||||||
|
UniProtKB:A0A8M2BD74
|
933 |
Interactions and Pathways
No data available
Plasmids
No data available