Gene

copb2

ID
ZDB-GENE-010724-7
Name
COPI coat complex subunit beta 2
Symbol
copb2 Nomenclature History
Previous Names
  • dop
  • dopey
  • sb:cb121
  • wu:fb30f06
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have structural molecule activity. Involved in notochord development and somite development. Predicted to localize to COPI vesicle coat. Is expressed in several structures, including axial mesoderm; cardiovascular system; digestive system; fin; and nervous system. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 19. Orthologous to human COPB2 (COPI coat complex subunit beta 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With copb2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary autosomal recessive microcephaly 19 Alliance ?Microcephaly 19, primary, autosomal recessive 617800
Associated With copb2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006692 Coatomer, WD associated region
Domain IPR017986 WD40-repeat-containing domain
Family IPR016453 Coatomer beta' subunit (COPB2)
Homologous_superfamily IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Repeat IPR001680 WD40 repeat
Repeat IPR020472 G-protein beta WD-40 repeat
Domain Details Per Protein
Protein Length Coatomer beta' subunit (COPB2) Coatomer, WD associated region G-protein beta WD-40 repeat Quinoprotein amine dehydrogenase, beta chain-like WD40 repeat WD40-repeat-containing domain WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A2R8RUW2 981
UniProtKB:Q6JWU7 934
UniProtKB:B3DH83 934
UniProtKB:B0R171 934
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations