ZFIN ID: ZDB-GENE-010724-7
Gene Name: COPI coat complex subunit beta 2
Gene Symbol: copb2    Nomenclature History

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Previous Names: dop, dopey, sb:cb121, wu:fb30f06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have structural molecule activity. Involved in notochord development and somite development. Predicted to localize to COPI vesicle coat. Is expressed in several structures, including axial mesoderm; cardiovascular system; digestive system; fin; and nervous system. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 19. Orthologous to human COPB2 (COPI coat complex subunit beta 2).
Genome Resources: Alliance (1),  Gene:114454 (1),  Ensembl(GRCz11):ENSDARG00000038743 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023673Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m341 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m475 Unknown Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39897 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tm18a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tr222b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tz226 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-copb2 N/A 1
    DISEASE ASSOCIATED WITH copb2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary autosomal recessive microcephaly 19 Alliance ?Microcephaly 19, primary, autosomal recessive 617800
    DISEASE ASSOCIATED WITH copb2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process notochord development (more)
    Cellular Component cytoplasm (more)
    Molecular Function structural molecule activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA copb2-201 (1)    Ensembl 3218
    ncRNA copb2-002 (1)    Ensembl 631
    copb2-003 (1)    Ensembl 1024
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM copb2 No data available
    MARKER RELATIONSHIPS
    copb2 Contained in: [BAC] CH211-119O8 (1)
    copb2 Contains: [SNP] rs3727648 (1), rs3727649 (1), rs3727650 (1)
    copb2 Encodes: [EST] cb121 (1), fb30f06 (1), wz178
    [cDNA] MGC:175021 (1), MGC:194073 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001001940 (1) 3170 nt
    Genomic GenBank:AL953896 (1) 158018 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8RUW2 (1) 981 aa
    Sequence Information (all 24)
    ORTHOLOGY for copb2 ( Chr: 2 )
    CITATIONS (44)