ZFIN ID: ZDB-GENE-010724-17
Gene Name: Ets2 repressor factor
Gene Symbol: erf    Nomenclature History

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Previous Names: fc22h01, wu:fc22h01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in head. Human ortholog(s) of this gene implicated in craniosynostosis. Orthologous to human ERF (ETS2 repressor factor).
Genome Resources: Alliance (1),  Gene:560416 (1),  Ensembl(GRCz11):ENSDARG00000063417 (2)
GENE EXPRESSION
All Expression Data: Fig. 5 from Pashay Ahi et al., 2016
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013535Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la020933Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la020934Tg Transgenic Insertion Unknown Unknown DNA
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH erf HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    craniosynostosis Alliance Craniosynostosis 4 600775
    Chitayat syndrome 617180
    DISEASE ASSOCIATED WITH erf VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription by RNA polymerase II (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA erf-202 (1)    Ensembl 4583
    erf-203 (1)    Ensembl 552
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM erf No data available
    MARKER RELATIONSHIPS
    erf Contained in: [BAC] CH211-272D23 (1)
    erf Contains: [SNP] rs3728955 (1), rs3728956 (1)
    erf Encodes: [EST] fc22h01 (1), wz1041
    [cDNA] MGC:198383 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001044927 (1) 4583 nt
    Genomic GenBank:BX119922 (1) 79729 nt
    Select Tool
    Polypeptide UniProtKB:B7ZVP1 (1) 621 aa
    Sequence Information (all 17)
    ORTHOLOGY for erf ( Chr: 19 )
    CITATIONS (29)