| ZFIN ID: ZDB-GENE-010716-2 |
| Gene Name: | iroquois homeobox 5a | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol: | irx5a Nomenclature History |
{{control.fieldName}} Edit
Attributions
|
||||||||||||
| Previous Names: | iro5 (1), ziro5 (1) | |||||||||||||
Add new Alias
Attributions for Alias: {{control.newAlias}}
Delete Alias:(Including Attributions) |
||||||||||||||
| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 7 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in embryonic skeletal joint development and regulation of chondrocyte differentiation. Predicted to localize to nucleus. Is expressed in several structures, including brain; head; hindbrain neural plate; mesoderm; and midbrain neural keel. Orthologous to human IRX5 (iroquois homeobox 5). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:573346 (1), Ensembl(GRCz11):ENSDARG00000034043 (2) | |||||||||||||
| All Expression Data: | 20 figures from 12 publications |
| Directly Submitted Expression Data: | 6 figures (15 images) from Thisse et al., 2004 [MGC:92554] |
| Wild-type Stages, Structures: | Gastrula:75%-epiboly (8.0h-9.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) |
|
|
| High Throughput Expression: | GEO (1) , Expression Atlas (1) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| el574 | Small Deletion | Unknown | Unknown | TALEN | |
| el576 | Small Deletion | Unknown | Unknown | TALEN | |
| sa17095 | Point Mutation | Unknown | Premature Stop | ENU |
|
Sequence Targeting Reagents
| Targeting Reagent | Created Alleles | Publications |
|---|---|---|
| TALEN1-irx5a | 1 |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Hamamy syndrome | 611174 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | embryonic skeletal joint development (more) |
| Cellular Component | nucleus (more) |
| Molecular Function | DNA binding (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
irx5a-201
(1)
|
1927 |
Select Tool
|
| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM irx5a
No data available
MARKER RELATIONSHIPS
| irx5a Contained in: | [BAC] CH211-191G22 (1), DKEY-224N5 (1) (order this) |
| irx5a Encodes: | [cDNA] MGC:92554 (1), MGC:191168 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001045227 (1) | 1922 nt |
Select Tool
|
| Genomic | GenBank:BX005202 (1) | 220733 nt | Blast at MegaBLAST |
| Polypeptide | UniProtKB:Q1LXU5 (1) | 446 aa |
Select Tool
|
ORTHOLOGY for irx5a (
Chr:
7
)
CITATIONS (37)