ZFIN ID: ZDB-GENE-010716-2
Gene Name: iroquois homeobox 5a
Gene Symbol: irx5a    Nomenclature History

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Previous Names: iro5 (1), ziro5 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in embryonic skeletal joint development and regulation of chondrocyte differentiation. Predicted to localize to nucleus. Is expressed in several structures, including brain; head; hindbrain neural plate; mesoderm; and midbrain neural keel. Orthologous to human IRX5 (iroquois homeobox 5).
Genome Resources: Alliance (1),  Gene:573346 (1),  Ensembl(GRCz11):ENSDARG00000034043 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
el574 Small Deletion Unknown Unknown TALEN
el576 Small Deletion Unknown Unknown TALEN
sa17095 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-irx5a 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH irx5a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hamamy syndrome 611174
    DISEASE ASSOCIATED WITH irx5a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process embryonic skeletal joint development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA irx5a-201 (1)    Ensembl 1927
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM irx5a No data available
    MARKER RELATIONSHIPS
    irx5a Contained in: [BAC] CH211-191G22 (1), DKEY-224N5 (1) (order this)
    irx5a Encodes: [cDNA] MGC:92554 (1), MGC:191168 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001045227 (1) 1922 nt
    Genomic GenBank:BX005202 (1) 220733 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q1LXU5 (1) 446 aa
    Sequence Information (all 27)
    ORTHOLOGY for irx5a ( Chr: 7 )
    CITATIONS (37)