Gene
irx5a
- ID
- ZDB-GENE-010716-2
- Name
- iroquois homeobox 5a
- Symbol
- irx5a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell development; neuron differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic skeletal joint development and regulation of chondrocyte differentiation. Is expressed in several structures, including brain; head; hindbrain neural plate; mesoderm; and midbrain neural keel. Orthologous to human IRX5 (iroquois homeobox 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 20 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92554 (15 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Hamamy syndrome | 611174 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Homeobox, conserved site | Homeobox domain | Homeobox KN domain | Homeobox-like domain superfamily | Iroquois-class homeodomain protein |
---|---|---|---|---|---|---|
UniProtKB:A4FVH4
|
290 | |||||
UniProtKB:Q6DHA2
|
272 | |||||
UniProtKB:A0A2R8QI66
|
272 | |||||
UniProtKB:Q1LXU5
|
446 | |||||
UniProtKB:Q90YM9
|
446 |
Interactions and Pathways
No data available
Plasmids
No data available