Gene

irx5a

ID

ZDB-GENE-010716-2

Name

iroquois homeobox 5a

Symbol

irx5a Nomenclature History

Previous Names

iro5 (1)
ziro5 (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cell development; neuron differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic skeletal joint development and regulation of chondrocyte differentiation. Is expressed in several structures, including brain; head; hindbrain neural plate; mesoderm; and midbrain neural keel. Orthologous to human IRX5 (iroquois homeobox 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

20 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:92554 (15 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With irx5a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Hamamy syndrome	611174

Associated With irx5a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeobox domain
Domain	IPR003893	Iroquois-class homeodomain protein
Domain	IPR008422	Homeobox KN domain
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily