ZFIN ID: ZDB-GENE-010619-2
Gene Name: connexin 27.5
Gene Symbol: cx27.5    Nomenclature History

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Previous Name: zfCx27.5 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have gap junction channel activity. Predicted to be involved in cell-cell signaling. Predicted to localize to connexin complex. Is expressed in several structures, including heart; liver; nervous system; otic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked dominant 1. Orthologous to human GJB1 (gap junction protein beta 1).
Genome Resources: Alliance (1),  Gene:114405 (1),  Ensembl(GRCz11):ENSDARG00000035553 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa40414 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cx27.5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease X-linked dominant 1 Alliance Charcot-Marie-Tooth neuropathy, X-linked dominant, 1 302800
    DISEASE ASSOCIATED WITH cx27.5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell communication (more)
    Cellular Component cell junction (more)
    Molecular Function gap junction channel activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cx27.5-201 (1)    Ensembl 1344
    cx27.5-202 (1)    Ensembl 1432
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cx27.5 No data available
    MARKER RELATIONSHIPS
    cx27.5 Contained in: [BAC] DKEY-110K5 (1) (order this)
    cx27.5 Encodes: [EST] eu281 (1)
    [cDNA] MGC:66010 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131811 (1) 1620 nt
    Genomic GenBank:AL929305 166110 nt
    Select Tool
    Polypeptide UniProtKB:Q2VJ87 (1) 254 aa
    Sequence Information (all 24)
    ORTHOLOGY for cx27.5 ( Chr: 5 )
    CITATIONS (28)