ZFIN ID: ZDB-GENE-010618-2
Gene Name: ephrin-B1
Gene Symbol: efnb1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have ephrin receptor binding activity. Involved in embryonic liver development and optic vesicle morphogenesis. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in craniofrontonasal syndrome and dysostosis. Is expressed in several structures, including alar plate midbrain region; central nervous system; hepatoblast; intestinal rod; and liver and biliary system. Orthologous to human EFNB1 (ephrin B1).
Genome Resources: Alliance (1),  Gene:114377 (1),  Ensembl(GRCz11):ENSDARG00000007723 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029093Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • nim26 Indel Unknown Frameshift, Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-efnb1 1
    MO1-efnb1 N/A 1
    MO2-efnb1 N/A 1
    MO3-efnb1 N/A 1
    DISEASE ASSOCIATED WITH efnb1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    craniofrontonasal syndrome Alliance Craniofrontonasal dysplasia 304110
    DISEASE ASSOCIATED WITH efnb1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process optic vesicle morphogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ephrin receptor binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA efnb1-201 (1)    Ensembl 1026
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM efnb1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(5xUAS-E1B:efnb1,cryaa:Citrine) cryaaE1BUAS Citrineefnb1 Danio rerio 1 1
    Tg2(5xUAS-E1B:efnb1,cryaa:Citrine) cryaaE1BUAS Citrineefnb1 Danio rerio 1 1
    MARKER RELATIONSHIPS
    efnb1 Contained in: [BAC] DKEY-48F17 (1) (order this)
    efnb1 Encodes: [EST] eu368 (1)
    [cDNA] MGC:194685 (1), MGC:194692 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131805 (1) 1026 nt
    Genomic GenBank:AL954373 (1) 220092 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8Q1M3 (1) 369 aa
    Sequence Information (all 21)
    ORTHOLOGY for efnb1 ( Chr: 5 )
    CITATIONS (29)