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ZIRC
ZFIN ID: ZDB-GENE-010508-1
Gene Name: beta-carotene oxygenase 1
Gene Symbol: bco1    Nomenclature History

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Previous Names: bcdo1 (1), bcdo, bcmo1 (1), bcox (1), bcmo1a

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Exhibits beta-carotene 15,15'-monooxygenase activity. Involved in eye photoreceptor cell differentiation and hindbrain development. Is expressed in gut; liver; neural crest; and ovary. Orthologous to human BCO1 (beta-carotene oxygenase 1).
Genome Resources: Alliance (1),  Gene:84039 (1),  Ensembl(GRCz11):ENSDARG00000104256 (1)
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 7 figures (4 images) from Thisse et al., 2004 [MGC:56569]
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-bco1 N/A 2
MO2-bco1 N/A 2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH bco1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Hypercarotenemia and vitamin A deficiency, autosomal dominant 115300
DISEASE ASSOCIATED WITH bco1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process eye photoreceptor cell differentiation (more)
Molecular Function beta-carotene 15,15'-monooxygenase activity (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR004294 (1)
  • Pfam:PF03055 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bco1-201 (1)    Ensembl 1790
    bco1-202 (1)    Ensembl 2088
    bco1-203 (1)    Ensembl 824
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bco1 No data available
    MARKER RELATIONSHIPS
    bco1 Contained in: [BAC] CH73-71F13 (1) (order this)
    [Fosmid] CH1073-356O14 (1) (order this)
    bco1 Encodes: [cDNA] MGC:56569 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131798 (1) 1896 bp
    Genomic GenBank:CU856172 (1) 99708 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IH96 (1) 565 aa
    Sequence Clusters UniGene:12383 (1)
    Sequence Information (all 18)
    ORTHOLOGY for bco1 ( Chr: 7 )
    CITATIONS (27)