Gene

cry3b

ID

ZDB-GENE-010426-5

Name

cryptochrome circadian regulator 3b

Symbol

cry3b Nomenclature History

Previous Names

cry1bb
cry2b
cry3b (1)
zcry2b (1)

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have DNA binding activity and FAD binding activity. Involved in negative regulation of transcription, DNA-templated. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including brain; endocrine system; eye; intestine; and liver and biliary system. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Orthologous to human CRY1 (cryptochrome circadian regulator 1).

Genome Resources

Note

None

Expression

All Expression Data

10 figures from 8 publications

Cross-Species Comparison

High Throughput Data

No data available

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cry3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Delayed sleep phase disorder, susceptibility to}	614163

Associated With cry3b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005101	Cryptochrome/DNA photolyase, FAD-binding domain
Domain	IPR006050	DNA photolyase, N-terminal
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily	IPR036134	Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily
Homologous_superfamily	IPR036155	Cryptochrome/photolyase, N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Cryptochrome/DNA photolyase, FAD-binding domain	Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily	Cryptochrome/photolyase, N-terminal domain superfamily	DNA photolyase, N-terminal	Rossmann-like alpha/beta/alpha sandwich fold
UniProtKB:A0A2R8QBE8 InterPro	639
UniProtKB:F1QY08 InterPro	502
UniProtKB:Q9I914 InterPro	638
UniProtKB:A0A0J9YJK7 InterPro	638
UniProtKB:A0A2R8QLW6 InterPro	650
UniProtKB:A0A2R8QPJ1 InterPro	641
UniProtKB:Q4V9Q3 InterPro	639
UniProtKB:F1QU08 InterPro	639

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	cry1bb-202 (1) Ensembl	2550 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cry1bb-002 (1) Ensembl	1068 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cry1bb-003 (1) Ensembl	922 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Gene Tree: Ensembl

Citations