Gene

cry3a

ID

ZDB-GENE-010426-4

Name

cryptochrome circadian regulator 3a

Symbol

cry3a Nomenclature History

Previous Names

cry1ba
cry2a
cry3a (1)
zcry2a (1)
zgc:110521

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have DNA binding activity and FAD binding activity. Involved in negative regulation of transcription, DNA-templated; response to light stimulus; and response to temperature stimulus. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including brain; eye; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome. Orthologous to human CRY1 (cryptochrome circadian regulator 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

16 figures from 12 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cry3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Delayed sleep phase disorder, susceptibility to}	614163

Associated With cry3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005101	Cryptochrome/DNA photolyase, FAD-binding domain
Domain	IPR006050	DNA photolyase, N-terminal
Homologous_superfamily	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
Homologous_superfamily	IPR036134	Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily
Homologous_superfamily	IPR036155	Cryptochrome/photolyase, N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	Cryptochrome/DNA photolyase, FAD-binding domain	Cryptochrome/DNA photolyase, FAD-binding domain-like superfamily	Cryptochrome/photolyase, N-terminal domain superfamily	DNA photolyase, N-terminal	Rossmann-like alpha/beta/alpha sandwich fold
UniProtKB:A0A2R8Q807 InterPro	570
UniProtKB:A0A2R8QN27 InterPro	553
UniProtKB:A0A2R8QCA4 InterPro	563
UniProtKB:Q9I915 InterPro	655
UniProtKB:Q503J5 InterPro	658
UniProtKB:B0S7X5 InterPro	659
UniProtKB:A0A2R8QLY8 InterPro	539

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	cry1ba-201 (1) Ensembl	2388 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	cry1ba-202 (1) Ensembl	4510 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	cry1ba-003 (1) Ensembl	698 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations