ZFIN ID: ZDB-GENE-010410-3
Gene Name: glycine receptor, alpha 4a
Gene Symbol: glra4a    Nomenclature History

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Previous Names: glra2, [a]Z2 (1), GlyR [a]Z2 (1), zgc:113093

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits extracellularly glycine-gated chloride channel activity. Predicted to contribute to chloride channel activity and glycine binding activity. Involved in several processes, including nervous system development; startle response; and thigmotaxis. Predicted to localize to integral component of plasma membrane; neuron projection; and synapse. Is expressed in eye; hindbrain; myotome; spinal cord; and telencephalon. Orthologous to human GLRA4 (glycine receptor alpha 4 (pseudogene)).
Genome Resources: Alliance (1),  Gene:83413 (1),  Ensembl(GRCz11):ENSDARG00000006865 (1)
GENE EXPRESSION
All Expression Data: 11 figures from 6 publications
Directly Submitted Expression Data: 4 figures (13 images) from Thisse et al., 2004 [IMAGE:6894068]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012592Tg Transgenic Insertion Unknown Unknown DNA
sa13968 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • udm108 Small Deletion Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-glra4a
    1
    CRISPR2-glra4a 1
    MO1-glra4a N/A 4
    MO2-glra4a N/A 2
    MO3-glra4a N/A 1
    MO4-glra4a N/A 1
    DISEASE ASSOCIATED WITH glra4a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH glra4a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chloride transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function extracellularly glycine-gated chloride channel activity (more)
    GO Terms (all 32)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA glra4a-202 (1)    Ensembl 2262
    ncRNA glra4a-002 (1)    Ensembl 855
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM glra4a No data available
    MARKER RELATIONSHIPS
    glra4a Contained in: [BAC] CH73-93E14 (1), CH211-127L12 (1)
    glra4a Encodes: [EST] IMAGE:6894068 (1)
    [cDNA] MGC:113093 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131782 (1) 2045 nt
    Genomic GenBank:BX005218 (1) 183670 nt
    Select Tool
    Polypeptide UniProtKB:F1Q832 (1) 459 aa
    Sequence Information (all 22)
    ORTHOLOGY for glra4a ( Chr: 14 )
    CITATIONS (39)