Gene

ncoa2

ID
ZDB-GENE-010406-3
Name
nuclear receptor coactivator 2
Symbol
ncoa2 Nomenclature History
Previous Names
  • grip1 (1)
  • src2 (2)
  • tif2 (1)
  • wu:fc41a10
  • wu:fe26a11
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Exhibits thyroid hormone receptor binding activity. Involved in chordate embryonic development; granulocyte differentiation; and primitive hemopoiesis. Predicted to localize to nucleus. Is expressed in several structures, including eye; gill; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NCOA2 (nuclear receptor coactivator 2).
Genome Resources
Note
None
Expression
All Expression Data
10 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Zhuravleva et al., 2008
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ncoa2 Human Ortholog
No data available
Associated With ncoa2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000014 PAS domain
Domain IPR010011 Domain of unknown function DUF1518
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Domain IPR013767 PAS fold
Domain IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
Domain IPR014935 Nuclear receptor coactivator, receptor-binding domain
Domain IPR032565 Domain of unknown function DUF4927
Family IPR017426 Nuclear receptor coactivator
Family IPR028822 Nuclear receptor coactivator 2
Homologous_superfamily IPR009110 Nuclear receptor coactivator, interlocking
Homologous_superfamily IPR035965 PAS domain superfamily
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Homologous_superfamily IPR037077 Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily
Domain Details Per Protein
Protein Length Domain of unknown function DUF1518 Domain of unknown function DUF4927 Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain Nuclear receptor coactivator Nuclear receptor coactivator 2 Nuclear receptor coactivator, interlocking Nuclear receptor coactivator, Ncoa-type, interlocking Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily Nuclear receptor coactivator, receptor-binding domain PAS domain PAS domain superfamily PAS fold
UniProtKB:F6NH98 1435
UniProtKB:Q98TW1 1505
UniProtKB:E7F5J8 1505
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations