ZFIN ID: ZDB-GENE-010406-3
Gene Name: nuclear receptor coactivator 2
Gene Symbol: ncoa2    Nomenclature History

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Previous Names: grip1 (1), src2 (2), tif2 (1), wu:fc41a10, wu:fe26a11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Exhibits thyroid hormone receptor binding activity. Involved in chordate embryonic development; granulocyte differentiation; and primitive hemopoiesis. Predicted to localize to nucleus. Is expressed in several structures, including eye; gill; integument; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NCOA2 (nuclear receptor coactivator 2).
Genome Resources: Alliance (1),  Gene:81884 (1),  Ensembl(GRCz11):ENSDARG00000017929 (2)
GENE EXPRESSION
All Expression Data: 9 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu757]
  7 figures (7 images) from Thisse et al., 2008 [af323989]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028597Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa5991 Point Mutation Unknown Splice Site ENU
    sa24460 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24461 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ncoa2 N/A 1
    MO2-ncoa2 N/A 1
    MO3-ncoa2 N/A 1
    DISEASE ASSOCIATED WITH ncoa2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ncoa2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component nucleus (more)
    Molecular Function thyroid hormone receptor binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ncoa2-202 (1)    Ensembl 7903
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ncoa2 No data available
    MARKER RELATIONSHIPS
    ncoa2 Contained in: [BAC] DKEY-81I11 (1) (order this), DKEY-237J21 (1) (order this)
    ncoa2 Contains: [STS] chunp6684
    ncoa2 Encodes: [EST] af323989 (1), eu757 (1), fc41a10, fe26a11
    [cDNA] MGC:194804 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131777 (1) 4958 nt
    Genomic GenBank:BX469920 (1) 123617 nt
    Select Tool
    Polypeptide UniProtKB:E7F5J8 (1) 1505 aa
    Sequence Information (all 30)
    ORTHOLOGY for ncoa2 ( Chr: 24 )
    CITATIONS (44)