ZFIN ID: ZDB-GENE-010404-1
Gene Name: NK2 homeobox 1
Gene Symbol: nkx2.1
Sequence Ontology ID : SO:0000704

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Previous Names: nk2.1b, nkx2.1b, nkx2.4b (1), titf1b (1), wu:fc31g10

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(Including Attributions)
Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have sequence-specific DNA binding activity; involved in hypothalamus development; predicted to localize to the nucleus; orthologous to human NKX2-1 (NK2 homeobox 1).
GENE EXPRESSION
All Expression Data: 27 figures from 21 publications
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Targeting reagents:
PHENOTYPE No data available
DISEASE ASSOCIATED WITH nkx2.1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
choreatic disease Chorea, hereditary benign 118700
papillary thyroid carcinoma {Thyroid cancer, nonmedullary, 1} 188550
Choreoathetosis, hypothyroidism, and neonatal respiratory distress 610978
DISEASE ASSOCIATED WITH nkx2.1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process hypothalamus development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR020479 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA nkx2.1-001 (1) 1808
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM nkx2.1 No data available
    MARKER RELATIONSHIPS
    nkx2.1Contained in: [BAC] DKEY-34N18 (1) (order this)
    nkx2.1Encodes: [EST] fc31g10
    [cDNA] MGC:194040 (1) (order this), MGC:194045 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131776 (1) 1773bp
    Genomic GenBank:BX511145 (1) 102544bp
    Select Tool
    Polypeptide UniProtKB:B3DH68 (1) 346aa
    Sequence Clusters UniGene:78792 (1)
    Sequence Information (all 17)
    OTHER nkx2.1 GENE PAGES
  • Alliance (1)
  • Gene:81883 (1)
  • VEGA:OTTDARG00000028829 (1)
  • Ensembl(GRCz11):ENSDARG00000019835 (2)
  • ORTHOLOGY for nkx2.1 (Chr: 17)
    CITATIONS (53)