ZFIN ID: ZDB-GENE-010404-1
Gene Name: NK2 homeobox 1
Gene Symbol: nkx2.1    Nomenclature History

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Previous Names: nk2.1b, nkx2.1b, nkx2.4b (1), titf1b (1), wu:fc31g10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in hypothalamus development. Predicted to localize to nucleus. Is expressed in brain; head; swim bladder; and thyroid follicle. Human ortholog(s) of this gene implicated in choreatic disease and thyroid gland papillary carcinoma. Orthologous to human NKX2-1 (NK2 homeobox 1).
Genome Resources: Alliance (1),  Gene:81883 (1),  Ensembl(GRCz11):ENSDARG00000019835 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-nkx2.1 N/A 2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH nkx2.1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
choreatic disease Alliance Chorea, hereditary benign 118700
thyroid gland papillary carcinoma Alliance {Thyroid cancer, nonmedullary, 1} 188550
Choreoathetosis, hypothyroidism, and neonatal respiratory distress 610978
DISEASE ASSOCIATED WITH nkx2.1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process hypothalamus development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nkx2.1-201 (1)    Ensembl 1808
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nkx2.1 No data available
MARKER RELATIONSHIPS
nkx2.1 Contained in: [BAC] DKEY-34N18 (1) (order this)
nkx2.1 Encodes: [EST] fc31g10
[cDNA] MGC:194040 (1), MGC:194045 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131776 (1) 1773 nt
Genomic GenBank:BX511145 (1) 102544 nt
Select Tool
Polypeptide UniProtKB:B3DH68 (1) 346 aa
Sequence Information (all 16)
ORTHOLOGY for nkx2.1 ( Chr: 17 )
CITATIONS (56)