Gene
nkx2.1
- ID
- ZDB-GENE-010404-1
- Name
- NK2 homeobox 1
- Symbol
- nkx2.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in hypothalamus development. Predicted to localize to nucleus. Is expressed in brain; head; swim bladder; and thyroid follicle. Human ortholog(s) of this gene implicated in choreatic disease and thyroid gland papillary carcinoma. Orthologous to human NKX2-1 (NK2 homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR017970 | Homeobox, conserved site |
Domain Details Per Protein
Protein | Length | Homeobox, conserved site |
---|---|---|
UniProtKB:Q98TX4
|
346 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
nkx2.1-201
(1)
|
Havana | 1808 nt |
Interactions and Pathways
No data available
Plasmids
No data available