Gene

cdk7

ID

ZDB-GENE-010320-2

Name

cyclin-dependent kinase 7

Symbol

cdk7 Nomenclature History

Previous Names

zgc:85821

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and regulation of cell cycle. Predicted to act upstream of or within protein phosphorylation. Predicted to be part of transcription factor TFIIK complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Orthologous to human CDK7 (cyclin dependent kinase 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:85821 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cdk7 Human Ortholog

No data available

Associated With cdk7 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Family	IPR037770	Cyclin-dependent kinase 7
Family	IPR050108	Cyclin-dependent kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length	Cyclin-dependent kinase	Cyclin-dependent kinase 7	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:Q2V6H0	InterPro	345
UniProtKB:Q6NWC5	InterPro	311

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	cdk7-201 (1) Ensembl	Ensembl	1,311 nt	Select Tool ZFIN BLAST
mRNA	cdk7-202 (1) Ensembl	Ensembl	1,110 nt	Select Tool ZFIN BLAST
mRNA	cdk7-203 (1) Ensembl	Ensembl	829 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations