ZFIN ID: ZDB-GENE-010320-1
Gene Name: cyclin-dependent kinase 1
Gene Symbol: cdk1    Nomenclature History

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Previous Names: cdc2, wu:fc30e01, zgc:92032

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Involved in regulation of mitotic cell cycle, embryonic. Predicted to localize to the cytoplasm; mitotic spindle; and nucleus. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder cancer. Orthologous to human CDK1 (cyclin dependent kinase 1).
Genome Resources: Alliance (1),  Gene:80973 (1),  Ensembl(GRCz11):ENSDARG00000087554 (1)
GENE EXPRESSION
All Expression Data: 5 figures from 5 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi3235Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tju1 Indel Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cdk1 1
    DISEASE ASSOCIATED WITH cdk1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cdk1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of mitotic cell cycle, embryonic (more)
    Cellular Component nucleus (more)
    Molecular Function ATP binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Binding_site IPR017441 Protein kinase, ATP binding site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdk1-201 (1)    Ensembl 1367
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cdk1 No data available
    MARKER RELATIONSHIPS
    cdk1 Contained in: [BAC] CH73-239N21 (1)
    cdk1 Encodes: [EST] fc30e01
    [cDNA] MGC:92032 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212564 (1) 1390 bp
    Genomic GenBank:CU861473 (1) 88180 bp
    Select Tool
    Polypeptide UniProtKB:Q7T3L7 (1) 302 aa
    Sequence Information (all 13)
    ORTHOLOGY for cdk1 ( Chr: 17 )
    CITATIONS (66)