ZFIN ID: ZDB-GENE-010319-1
Gene Name: dishevelled segment polarity protein 3a
Gene Symbol: dvl3a    Nomenclature History

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Previous Names: dvl3, wu:fb75f04, wu:fi22h02, wu:fp61b09

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have frizzled binding activity. Involved in canonical Wnt signaling pathway; convergent extension involved in axis elongation; and post-anal tail morphogenesis. Localizes to cell cortex and spindle. Is expressed in liver. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3. Orthologous to human DVL3 (dishevelled segment polarity protein 3).
Genome Resources: Alliance (1),  Gene:80972 (1),  Ensembl(GRCz11):ENSDARG00000015707 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55261]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14810 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19682 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31259 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32847 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sdu16 Small Deletion Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-dvl3a N/A 6
    TALEN1-dvl3a 2
    DISEASE ASSOCIATED WITH dvl3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant Robinow syndrome 3 Alliance Robinow syndrome, autosomal dominant 3 616894
    DISEASE ASSOCIATED WITH dvl3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process canonical Wnt signaling pathway (more)
    Cellular Component cell cortex (more)
    Molecular Function frizzled binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dvl3a-201 (1)    Ensembl 3009
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM dvl3a No data available
    MARKER RELATIONSHIPS
    dvl3a Contained in: [Fosmid] CH1073-20K7 (1), CH1073-170O4 (1)
    dvl3a Encodes: [EST] fb75f04, fi22h02, fp61b09
    [cDNA] MGC:55261 (1), MGC:114008 (1), MGC:192732 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131757 (1) 2437 nt
    Genomic GenBank:CU633992 (1) 39137 nt
    Select Tool
    Polypeptide UniProtKB:B8JMI2 (1) 676 aa
    Sequence Information (all 29)
    ORTHOLOGY for dvl3a ( Chr: 2 )
    CITATIONS (42)