ZFIN ID: ZDB-GENE-010306-3
Gene Name: slit homolog 2 (Drosophila)
Gene Symbol: slit2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have Roundabout binding activity and heparin binding activity. Involved in endocardial progenitor cell migration to the midline involved in heart field formation; generation of neurons; and morphogenesis of a branching structure. Predicted to localize to the extracellular space. Is expressed in several structures, including axial mesoderm; forebrain neural tube; hypochord; nervous system; and neural plate. Orthologous to human SLIT2 (slit guidance ligand 2).
Genome Resources: Alliance (1),  Gene:80353 (1),  Ensembl(GRCz11):ENSDARG00000004246 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028107Tg Transgenic Insertion Unknown Unknown DNA
sa231 Point Mutation Unknown Premature Stop ENU
sa1772 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12974 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15818 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39610 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko456a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko456b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-slit2 1
    MO1-slit2 N/A 4
    MO2-slit2 N/A 1
    MO3-slit2 N/A 1
    DISEASE ASSOCIATED WITH slit2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH slit2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process central nervous system projection neuron axonogenesis (more)
    Cellular Component extracellular region (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR013032 EGF-like, conserved site
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    Domain IPR000372 Leucine-rich repeat N-terminal domain
    Domain IPR000483 Cysteine-rich flanking region, C-terminal
    Domain IPR000742 EGF-like domain
    Domain IPR001791 Laminin G domain
    Domain IPR001881 EGF-like calcium-binding domain
    Domain IPR003645 Follistatin-like, N-terminal
    Domain IPR006207 Cystine knot, C-terminal
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Repeat IPR001611 Leucine-rich repeat
    Repeat IPR003591 Leucine-rich repeat, typical subtype
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slit2-201 (1)    Ensembl 7426
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slit2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:slit2-GFP) hsp70l GFPslit2 Danio rerio 5 15
    MARKER RELATIONSHIPS
    slit2 Contained in: [BAC] CH211-250N21 (1)
    [Fosmid] CH1073-144H23 (1), CH1073-162A7 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131735 (1) 4539 nt
    Genomic GenBank:CU896673 (1) 107021 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8RXU4 (1) 1521 aa
    Sequence Information (all 49)
    ORTHOLOGY for slit2 ( Chr: 1 )
    CITATIONS (57)