Gene

slit2

ID
ZDB-GENE-010306-3
Name
slit homolog 2 (Drosophila)
Symbol
slit2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have Roundabout binding activity and heparin binding activity. Involved in endocardial progenitor cell migration to the midline involved in heart field formation; generation of neurons; and morphogenesis of a branching structure. Predicted to localize to extracellular region. Is expressed in several structures, including axial mesoderm; forebrain neural tube; hypochord; nervous system; and neural plate. Orthologous to human SLIT2 (slit guidance ligand 2).
Genome Resources
Note
None
Expression
All Expression Data
20 figures from 17 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slit2 Human Ortholog
No data available
Associated With slit2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000372 Leucine-rich repeat N-terminal domain
Domain IPR000483 Cysteine-rich flanking region, C-terminal
Domain IPR000742 EGF-like domain
Domain IPR001791 Laminin G domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR003645 Follistatin-like, N-terminal
Domain IPR006207 Cystine knot, C-terminal
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Domain Details Per Protein
Protein Length Concanavalin A-like lectin/glucanase domain superfamily Cysteine-rich flanking region, C-terminal Cystine knot, C-terminal EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Follistatin-like, N-terminal Growth factor receptor cysteine-rich domain superfamily Laminin G domain Leucine-rich repeat Leucine-rich repeat domain superfamily Leucine-rich repeat N-terminal domain Leucine-rich repeat, typical subtype
UniProtKB:F1QQE4 1512
UniProtKB:A0A0R4IFT2 1475
UniProtKB:A0A2R8RXU4 1521
UniProtKB:A0A2R8RID6 1484
UniProtKB:Q9DE36 1512
UniProtKB:A0A2R8RWP7 1489
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations