ZFIN ID: ZDB-GENE-010302-1
Gene Name: forkhead box C1a
Gene Symbol: foxc1a    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Exhibits chromatin binding activity. Involved in several processes, including animal organ development; regulation of signal transduction; and vasculature development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in eye and adnexa disease (multiple); lymphedema; nephritis; obesity; and type 2 diabetes mellitus. Is expressed in several structures, including cardiovascular system; head; mesenchyme; mesoderm; and somite. Orthologous to several human genes including FOXC1 (forkhead box C1).
Genome Resources: Alliance (1),  Gene:100148408 (1),  Ensembl(GRCz11):ENSDARG00000091481 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
el542 Small Deletion Unknown Unknown TALEN
el543 Small Deletion Unknown Unknown TALEN
nju18 Indel Unknown Unknown TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • nju19 Insertion Unknown Unknown TALEN
    nju60 Indel Unknown Unknown TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • p162 Point Mutation Unknown Premature Stop ENU
    sa10371 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ua1017 Small Deletion Unknown Unknown CRISPR
    PHENOTYPE
    Data: 27 figures from 10 publications
    Observed in:
    DISEASE ASSOCIATED WITH foxc1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Axenfeld-Rieger syndrome type 3 Alliance Axenfeld-Rieger syndrome, type 3 602482
    iridogoniodysgenesis syndrome Alliance Anterior segment dysgenesis 3, multiple subtypes 601631
    DISEASE ASSOCIATED WITH foxc1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adrenal gland development (more)
    Cellular Component nucleus (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 31)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001766 Fork head domain
    Conserved_site IPR018122 Fork head domain conserved site1
    Conserved_site IPR030456 Fork head domain conserved site 2
    Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
    Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA foxc1a-201 (1)    Ensembl 2175
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM foxc1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(UAS:foxc1a,cryaa:Cerulean) cryaaUAS Ceruleanfoxc1a Danio rerio 1 1
    MARKER RELATIONSHIPS
    foxc1a Contained in: [Fosmid] CH1073-434G19 (1)
    foxc1a Encodes: [cDNA] MGC:63879 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131728 (1) 2231 bp
    Genomic GenBank:CU929125 (1) 28376 bp
    Select Tool
    Polypeptide UniProtKB:Q9DE25 (1) 476 aa
    Sequence Clusters UniGene:82483 (1)
    Sequence Information (all 18)
    ORTHOLOGY for foxc1a ( Chr: 2 )
    CITATIONS (68)