ZFIN is now using GRCz12tu for Genomic Data
Gene
gdnfa
- ID
- ZDB-GENE-010226-1
- Name
- glial cell derived neurotrophic factor a
- Symbol
- gdnfa Nomenclature History
- Previous Names
-
- gdnf
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables MAP kinase kinase kinase activity. Acts upstream of or within nervous system development; protein-containing complex assembly; and regulation of dopaminergic neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; eye; gut; intermediate mesoderm; and lateral line system. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; Parkinsonism; alcohol dependence; alcohol use disorder; and heroin dependence. Orthologous to human GDNF (glial cell derived neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| {Hirschsprung disease, susceptibility to, 3} | 613711 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001839 | Transforming growth factor-beta, C-terminal |
| Domain | IPR047020 | Glial cell line-derived neurotrophic factor, TGF-beta-like domain |
| Family | IPR016649 | Glial cell line-derived neurotrophic factor |
| Family | IPR043401 | Glial cell line-derived neurotrophic factor family |
| Homologous_superfamily | IPR029034 | Cystine-knot cytokine |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | Glial cell line-derived neurotrophic factor | Glial cell line-derived neurotrophic factor family | Glial cell line-derived neurotrophic factor, TGF-beta-like domain | Transforming growth factor-beta, C-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q98TU0 | InterPro PDB | 235 | |||||
| UniProtKB:A7E220 | InterPro | 235 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers