Gene

gdnfa

ID
ZDB-GENE-010226-1
Name
glial cell derived neurotrophic factor a
Symbol
gdnfa Nomenclature History
Previous Names
  • gdnf
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Exhibits MAP kinase kinase kinase activity. Involved in enteric nervous system development and protein-containing complex assembly. Predicted to localize to extracellular space. Is expressed in several structures, including brain; digestive system; eye; intermediate mesoderm; and lateral line system. Human ortholog(s) of this gene implicated in Hirschsprung's disease; congenital central hypoventilation syndrome; epilepsy; and pheochromocytoma. Orthologous to human GDNF (glial cell derived neurotrophic factor).
Genome Resources
Note
None
Expression
All Expression Data
21 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gdnfa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital central hypoventilation syndrome Alliance Central hypoventilation syndrome 209880
pheochromocytoma Alliance {Pheochromocytoma, modifier of} 171300
{Hirschsprung disease, susceptibility to, 3} 613711
Associated With gdnfa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR016649 Glial cell line-derived neurotrophic factor
Family IPR043401 Glial cell line-derived neurotrophic factor family
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Glial cell line-derived neurotrophic factor Glial cell line-derived neurotrophic factor family Transforming growth factor-beta, C-terminal
UniProtKB:A7E220 235
UniProtKB:Q98TU0 235
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations