Gene
gdnfa
- ID
- ZDB-GENE-010226-1
- Name
- glial cell derived neurotrophic factor a
- Symbol
- gdnfa Nomenclature History
- Previous Names
-
- gdnf
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Enables MAP kinase kinase kinase activity. Acts upstream of or within nervous system development; protein-containing complex assembly; and regulation of dopaminergic neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; eye; gut; intermediate mesoderm; and lateral line system. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Parkinsonism; and epilepsy. Orthologous to human GDNF (glial cell derived neurotrophic factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
{Hirschsprung disease, susceptibility to, 3} | 613711 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Cystine-knot cytokine | Glial cell line-derived neurotrophic factor | Glial cell line-derived neurotrophic factor family | Transforming growth factor-beta, C-terminal |
---|---|---|---|---|---|
UniProtKB:A7E220
|
235 | ||||
UniProtKB:Q98TU0
|
235 |
Interactions and Pathways
No data available
Plasmids
No data available