Gene

gdnfa

ID
ZDB-GENE-010226-1
Name
glial cell derived neurotrophic factor a
Symbol
gdnfa Nomenclature History
Previous Names
  • gdnf
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Enables MAP kinase kinase kinase activity. Acts upstream of or within nervous system development; protein-containing complex assembly; and regulation of dopaminergic neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; eye; gut; intermediate mesoderm; and lateral line system. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Parkinsonism; and epilepsy. Orthologous to human GDNF (glial cell derived neurotrophic factor).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
25 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gdnfa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Hirschsprung disease, susceptibility to, 3} 613711
Associated With gdnfa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR016649 Glial cell line-derived neurotrophic factor
Family IPR043401 Glial cell line-derived neurotrophic factor family
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Glial cell line-derived neurotrophic factor Glial cell line-derived neurotrophic factor family Transforming growth factor-beta, C-terminal
UniProtKB:A7E220 235
UniProtKB:Q98TU0 235
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations