ZFIN ID: ZDB-GENE-010202-3
Gene Name: mitogen-activated protein kinase kinase 6
Gene Symbol: map2k6    Nomenclature History

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Previous Names: map2k3 (1), MKK3 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have MAP kinase kinase activity and protein serine/threonine kinase activity. Involved in activation of MAPK activity. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6).
Genome Resources: Alliance (1),  Gene:65239 (1),  Ensembl(GRCz11):ENSDARG00000099184 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55210]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH map2k6 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH map2k6 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process activation of MAPK activity (more)
Cellular Component cytoplasm (more)
Molecular Function ATP binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA map2k6-201 (1)    Ensembl 1734
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM map2k6 No data available
MARKER RELATIONSHIPS
map2k6 Contained in: [BAC] DKEY-105G4 (1) (order this), DKEY-113D16 (1) (order this)
map2k6 Encodes: [cDNA] MGC:55210 (1), MGC:86568 (1), MGC:192910 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131724 (1) 1738 nt
Genomic GenBank:AL954682 (1) 181276 nt
Select Tool
Polypeptide UniProtKB:A0A286Y813 (1) 363 aa
Sequence Information (all 27)
ORTHOLOGY for map2k6 ( Chr: 12 )
CITATIONS (28)