Gene

fgf8b

ID
ZDB-GENE-010122-1
Name
fibroblast growth factor 8 b
Symbol
fgf8b Nomenclature History
Previous Names
  • fgf17
  • fgf17a
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Predicted to be involved in several processes, including fibroblast growth factor receptor signaling pathway; heart development; and positive regulation of macromolecule metabolic process. Predicted to localize to cytoplasm and extracellular space. Is expressed in several structures, including anterior macula; brain; midbrain hindbrain boundary neural rod; optic vesicle; and otic vesicle. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Orthologous to human FGF8 (fibroblast growth factor 8).
Genome Resources
Note
Reifers et al. (2000) originally reported this gene as fgf17a with synteny to Mmu Fgf17. Kikuta et al. (2007) present mapping data showing fgf17a (fgf8b) as syntenic to Hsa Chr. 1. These data, along with BLAST results, led to changing fgf17a to fgf8b.
Comparative Information
Expression
All Expression Data
17 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fgf8b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypogonadotropic hypogonadism 6 with or without anosmia Alliance Hypogonadotropic hypogonadism 6 with or without anosmia 612702
Associated With fgf8b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR002209 Fibroblast growth factor family
Family IPR026224 Protein DPCD
Family IPR028249 Fibroblast growth factor 8
Homologous_superfamily IPR008996 Cytokine IL1/FGF
Domain Details Per Protein
Protein Length Cytokine IL1/FGF Fibroblast growth factor 8 Fibroblast growth factor family Protein DPCD
UniProtKB:Q805B2 212
UniProtKB:A0A2R8PZ25 59
UniProtKB:B3DJ36 212
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations