Gene

alas1

ID
ZDB-GENE-001229-2
Name
aminolevulinate, delta-, synthase 1
Symbol
alas1 Nomenclature History
Previous Names
  • ALAS-N
  • unm_sm350
  • wu:fb58d01
  • wu:fi12g09
  • wu:fq33a02
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have 5-aminolevulinate synthase activity and pyridoxal phosphate binding activity. Involved in neutrophil differentiation. Predicted to localize to mitochondrial matrix. Is expressed in several structures, including EVL; digestive system; periderm; polster; and pronephros. Orthologous to human ALAS1 (5'-aminolevulinate synthase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With alas1 Human Ortholog
No data available
Associated With alas1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site
Domain IPR004839 Aminotransferase, class I/classII
Domain IPR010961 Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase
Domain IPR015118 5-aminolevulinate synthase presequence
Homologous_superfamily IPR015421 Pyridoxal phosphate-dependent transferase, major domain
Homologous_superfamily IPR015424 Pyridoxal phosphate-dependent transferase
Domain Details Per Protein
Protein Length 5-aminolevulinate synthase presequence Aminotransferase, class I/classII Aminotransferase, class-II, pyridoxal-phosphate binding site Pyridoxal phosphate-dependent transferase Pyridoxal phosphate-dependent transferase, major domain Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase
UniProtKB:Q7T2F0 613
UniProtKB:A0A140LH72 247
UniProtKB:F1RB22 621
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations