ZFIN ID: ZDB-GENE-001030-3
Gene Name: paired box 8
Gene Symbol: pax8

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(Including Attributions)
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 47 figures from 32 publications
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  ectoderm, epibranchial field, epibranchial ganglion, hindbrain (all 30) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
nia03Gt Transgenic Insertion Unknown Unknown DNA
sa2216 Point Mutation Unknown Premature Stop ENU
sa31494 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-pax8, MO2-pax8, MO3-pax8, MO4-pax8, MO5-pax8 (all 11) expand
    PHENOTYPE
    Data: 4 figures from 3 publications
    Observed in: hair cell, lateral crista, midbrain hindbrain boundary, otic placode (all 6) expand
    DISEASE ASSOCIATED WITH pax8 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    congenital hypothyroidism Hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 218700
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior pattern specification involved in pronephros development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001523 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR011991 (1)
  • InterPro:IPR022130 (1)
  • PROSITE:PS00034 (1)
  • PROSITE:PS51057 (1)
  • Pfam:PF00292 (1)
  • Pfam:PF12403 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pax8
    Gt(pax8:DsRedx), Tg(hsp70l:pax8)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPSNo data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001339857 (1) 1517bp
    Genomic GenBank:CABZ01094912 (1) 5571bp
    Polypeptide UniProtKB:F1Q9Q9 (1) 448aa
    Sequence Clusters UniGene:8177 (1)
    Sequence Information (all 11)
    OTHER pax8 GENE PAGES
  • Gene:60637 (1)
  • Ensembl(GRCz10):ENSDARG00000015879 (1)
  • ORTHOLOGY for pax8 (Chr: 5)
    Species Symbol Chromosome Accession # Evidence
    Human PAX8 2
  • Gene:7849
  • OMIM:167415
  • HGNC:8622
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Mouse Pax8 2
  • MGI:97492
  • Gene:18510
  • Amino acid sequence comparison (1)
    Coincident expression (1)
    Download Curated Orthology
    CITATIONS (89)