Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-001030-3
Gene Name: paired box 8
Gene Symbol: pax8
Location: Chr: 5   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 44 figures from 29 publications
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  ectoderm, epibranchial field, epibranchial ganglion, intermediate mesoderm (all 24) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 3 genotypes
Alleles: nia03Gt
Knockdown reagents: MO1-pax8, MO2-pax8, MO3-pax8, MO4-pax8, MO5-pax8 (all 11) expand
PHENOTYPE
Data: 4 figures from 3 publications
Observed in: hair cell, lateral crista, midbrain hindbrain boundary, otic placode (all 6) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 218700
GENE ONTOLOGY
Ontology GO Term
Biological Process otic placode formation (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001523 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR011991 (1)
  • InterPro:IPR022130 (1)
  • PROSITE:PS00034 (1)
  • PROSITE:PS51057 (1)
  • Pfam:PF00292 (1)
  • Pfam:PF12403 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM pax8
    Gt(pax8:DsRedx), Tg(hsp70l:pax8)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001339857 (1) 1528 bp
    Genomic GenBank:CABZ01094912 (1) 5571 bp
    Polypeptide UniProtKB:F1Q9Q9 (1) 429 aa
    Sequence Clusters UniGene:8177 (1)
    Sequence Information (all 13)
    OTHER pax8 GENE PAGES
  • Gene:60637 (1)
  • Ensembl(Zv9):ENSDARG00000015879 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL CE
    Zebrafish pax8 5  
    Human PAX8 2 (2q13)
  • OMIM:167415
  • Gene:7849
  • Mouse Pax8 2 ( 16.43 cM)
  • MGI:97492
  • Gene:18510
  • Orthology Details
    CITATIONS (74)