ZFIN ID: ZDB-GENE-001030-3
Gene Name: paired box 8
Gene Symbol: pax8
Location: Chr: 5 Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 46 figures from 31 publications
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  ectoderm, epibranchial field, epibranchial ganglion, hindbrain (all 30) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
nia03Gt Transgenic Insertion
Targeting reagents: MO1-pax8, MO2-pax8, MO3-pax8, MO4-pax8, MO5-pax8 (all 11) expand
PHENOTYPE
Data: 4 figures from 3 publications
Observed in: hair cell, lateral crista, midbrain hindbrain boundary, otic placode (all 6) expand
DISEASE ASSOCIATED WITH pax8 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
congenital hypothyroidism Hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 218700
GENE ONTOLOGY
Ontology GO Term
Biological Process anterior/posterior pattern specification involved in pronephros development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001523 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR011991 (1)
  • InterPro:IPR022130 (1)
  • PROSITE:PS00034 (1)
  • PROSITE:PS51057 (1)
  • Pfam:PF00292 (1)
  • Pfam:PF12403 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pax8
    Gt(pax8:DsRedx), Tg(hsp70l:pax8)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPSNo data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009299769 (1) 1527bp
    Genomic GenBank:CABZ01094912 (1) 5571bp
    Polypeptide UniProtKB:F1Q9Q9 (1) 448aa
    Sequence Clusters UniGene:8177 (1)
    Sequence Information (all 13)
    OTHER pax8 GENE PAGES
  • Gene:60637 (1)
  • Ensembl(GRCz10):ENSDARG00000015879 (1)
  • ORTHOLOGY for pax8 (Chr: 5)
    Species Symbol Chromosome Accession # Evidence
    Human PAX8 2
  • Gene:7849
  • OMIM:167415
  • HGNC:8622
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Mouse Pax8 2
  • MGI:97492
  • Gene:18510
  • Amino acid sequence comparison (1)
    Coincident expression (1)
    Download Curated Orthology
    CITATIONS (81)