ZFIN ID: ZDB-GENE-001030-3
Gene Name: paired box 8
Gene Symbol: pax8    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have DNA binding activity. Involved in anterior/posterior pattern specification involved in pronephros development; otic placode formation; and peripheral nervous system development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in congenital hypothyroidism and congenital nongoitrous hypothyroidism 2. Is expressed in several structures, including endocrine system; mesoderm; nervous system; neurogenic field; and pronephros. Orthologous to human PAX8 (paired box 8).
Genome Resources: Alliance (1),  Gene:60637 (1),  Ensembl(GRCz11):ENSDARG00000015879 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
nia03Gt Transgenic Insertion Unknown Unknown DNA
sa2216 Point Mutation Unknown Premature Stop ENU
sa31494 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pax8 N/A 1
    MO2-pax8 N/A 1
    MO3-pax8 N/A 1
    MO4-pax8 N/A 4
    MO5-pax8 N/A 4
    MO6-pax8 N/A 7
    MO7-pax8 N/A 6
    MO8-pax8 N/A 1
    MO9-pax8 N/A 1
    MO10-pax8 N/A 1
    MO11-pax8 N/A 1
    DISEASE ASSOCIATED WITH pax8 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital nongoitrous hypothyroidism 2 Alliance Hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 218700
    DISEASE ASSOCIATED WITH pax8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior pattern specification involved in pronephros development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001523 Paired domain
    Domain IPR022130 Paired-box protein 2 C-terminal
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pax8
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Gt(pax8:DsRedx) pax8 DsRedx Danio rerio 1 8
    Tg(hsp70l:pax8) hsp70l pax8 Danio rerio 1 2
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_001339857 (1) 1429 nt
    Genomic GenBank:CABZ01094912 (1) 5571 nt
    Polypeptide UniProtKB:F1Q9Q9 (1) 448 aa
    Sequence Information (all 14)
    ORTHOLOGY for pax8 ( Chr: 5 )
    CITATIONS (117)