ZFIN ID: ZDB-GENE-001030-2
Gene Name: paired box 5
Gene Symbol: pax5    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have DNA binding activity. Involved in vestibular receptor cell development and vestibular reflex. Predicted to localize to nucleus. Is expressed in several structures, including B cell; chordo neural hinge; hindbrain neural keel; midbrain hindbrain boundary neural keel; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; focal segmental glomerulosclerosis 7; and renal coloboma syndrome. Orthologous to several human genes including PAX5 (paired box 5).
Genome Resources: Alliance (1),  Gene:60636 (1),  Ensembl(GRCz11):ENSDARG00000037383 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16357 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19482 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko418a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • zko418b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-pax5 1
    MO1-pax5 N/A 1
    MO2-pax5 N/A 1
    MO3-pax5 N/A 1
    MO4-pax5 N/A 1
    MO5-pax5 N/A 1
    DISEASE ASSOCIATED WITH pax5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Leukemia, acute lymphoblastic, susceptibility to, 3} 615545
    DISEASE ASSOCIATED WITH pax5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process vestibular receptor cell development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pax5-201 (1)    Ensembl 1188
    pax5-202 (1)    Ensembl 1675
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pax5 No data available
    MARKER RELATIONSHIPS
    pax5 Contained in: [BAC] CH211-134C9 (1)
    pax5 Encodes: [EST] eu596 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131638 (1) 1675 nt
    Genomic GenBank:BX511134 (1) 188290 nt
    Select Tool
    Polypeptide UniProtKB:F1QGF8 (1) 396 aa
    Sequence Information (all 16)
    ORTHOLOGY for pax5 ( Chr: 1 )
    CITATIONS (72)