Gene

pax5

ID
ZDB-GENE-001030-2
Name
paired box 5
Symbol
pax5 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in vestibular receptor cell development and vestibular reflex. Predicted to localize to nuclear chromatin. Is expressed in several structures, including B cell; chordo neural hinge; hindbrain neural keel; midbrain hindbrain boundary neural keel; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; focal segmental glomerulosclerosis 7; and renal coloboma syndrome. Orthologous to several human genes including PAX5 (paired box 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
48 figures from 32 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Kwak et al., 2006
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pax5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Leukemia, acute lymphoblastic, susceptibility to, 3} 615545
Associated With pax5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001523 Paired domain
Domain IPR022130 Paired-box protein 2 C-terminal
Domain IPR043182 Paired DNA-binding domain
Family IPR043565 PAX family
Homologous_superfamily IPR009057 Homedomain-like superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Homedomain-like superfamily Paired-box protein 2 C-terminal Paired DNA-binding domain Paired domain PAX family Winged helix-like DNA-binding domain superfamily
UniProtKB:A0A8M2BI63 423
UniProtKB:F1QGF8 396
UniProtKB:A0A8M2BI96 422
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations