Gene
robo2
- ID
- ZDB-GENE-001019-1
- Name
- roundabout, axon guidance receptor, homolog 2 (Drosophila)
- Symbol
- robo2 Nomenclature History
- Previous Names
-
- ast
- astray
- sb:eu937
- unp1881
- zmp:0000000549 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable axon guidance receptor activity. Acts upstream of or within several processes, including axon development; regulation of extent of cell growth; and sensory perception of touch. Predicted to be located in membrane. Predicted to be active in neuron projection. Is expressed in several structures, including digestive system; dorsal fin; nervous system; spleen; and trigeminal placode. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu937 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- 30 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
vesicoureteral reflux | Alliance | Vesicoureteral reflux 2 | 610878 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR003598 | Immunoglobulin subtype 2 |
Domain | IPR003599 | Immunoglobulin subtype |
Domain | IPR003961 | Fibronectin type III |
Domain | IPR007110 | Immunoglobulin-like domain |
Domain | IPR013098 | Immunoglobulin I-set |
Domain | IPR013106 | Immunoglobulin V-set domain |
Family | IPR032986 | Roundabout homologue 1 |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
Protein | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype | Immunoglobulin subtype 2 | Immunoglobulin V-set domain | Roundabout homologue 1 |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q1LY64
|
128 | ||||||||||
UniProtKB:Q804R9
|
20 | ||||||||||
UniProtKB:A0A2R8Q4U8
|
136 | ||||||||||
UniProtKB:F1QBD4
|
1387 | ||||||||||
UniProtKB:Q19S04
|
111 | ||||||||||
UniProtKB:A4JYH1
|
862 | ||||||||||
UniProtKB:Q90Z70
|
1513 | ||||||||||
UniProtKB:B8K0D7
|
399 | ||||||||||
UniProtKB:Q19S05
|
46 |
- Genome Browsers
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA | ottdart00000001997 (1) | 226 nt | |
mRNA |
robo2-203
(1)
|
552 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance