ZFIN Gene: robo2

ZFIN ID: ZDB-GENE-001019-1

ZFIN ID: ZDB-GENE-001019-1

Gene Name:

roundabout, axon guidance receptor, homolog 2 (Drosophila)

Gene Symbol:

robo2

Sequence Ontology ID :

SO:0000704

Previous Names:

ast, astray, sb:eu937, unp1881, zmp:0000000549 (1)

Location:

Chr: 15 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Involved in cell morphogenesis; nervous system development; and sensory perception of touch. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in ...

GENE EXPRESSION
All Expression Data:	33 figures from 21 publications
Directly Submitted Expression Data:	6 figures (5 images) from Thisse et al., 2005 [eu937]
Wild-type Stages, Structures:	Blastula:1k-cell (3.0h-3.33h) to Adult (90d-730d, breeding adult)
	brain central nervous system diencephalon dopaminergic neuron digestive system dorsal fin dorsal telencephalon ventro-lateral region dorso-rostral cluster eye forebrain gill hindbrain liver midbrain olfactory epithelium olfactory placode optic tectum primitive olfactory epithelium retinal ganglion cell retinal ganglion cell layer spleen statoacoustic (VIII) ganglion neuron trigeminal ganglion trigeminal placode unspecified ventro-caudal cluster ventro-rostral cluster whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la019390Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la019391Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
robo2_unspecified	Unspecified	Unknown	Unknown
sa6395	Point Mutation	Unknown	Splice Site	ENU
sa10275	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa14991	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa24995	Point Mutation	Unknown	Splice Site	ENU
sa30686	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35974	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35975	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35976	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa42608	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
te284	Point Mutation	Unknown	Missense	ENU	European Zebrafish Resource Center (EZRC) (order this)
te378	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
ti272z	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this)
tl231	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)

Targeting reagents:

PHENOTYPE

Data:

28 figures from 13 publications

Observed in:

DISEASE ASSOCIATED WITH robo2 HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
vesicoureteral reflux	Vesicoureteral reflux 2	610878

DISEASE ASSOCIATED WITH robo2 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	anterior/posterior axon guidance (more)
Cellular Component	integral component of membrane (more)
Molecular Function	protein binding (more)

GO Terms (all 14)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR003598 (1) InterPro:IPR003599 (1) InterPro:IPR003961 (1) InterPro:IPR007110 (1) InterPro:IPR013098 (1) InterPro:IPR013106 (1) InterPro:IPR013783 (1) InterPro:IPR036116 (1) InterPro:IPR036179 (1)	PROSITE:PS50835 (1) PROSITE:PS50853 (1)	Pfam:PF00041 (1) Pfam:PF07679 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	ottdart00000001997 (1)	226	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	robo2-203 (1)	552	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Withdrawn Transcripts
transcript	ottdart00000039974 (1)	1200	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION No description available

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM robo2 No data available

MARKER RELATIONSHIPS

robo2Contained in:	[BAC] CH211-15J21 (1) (order this) [Fosmid] CH1073-132M13 (1) (order this) [PAC] BUSM1-181A10 (1) (order this)
robo2Encodes:	[EST] eu937 (1) [cDNA] cssl:d829 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131633 (1)	4871bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX088709 (1)	156236bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q90Z70 (1)	1513aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:83334 (1)

Sequence Information (all 93)

OTHER robo2 GENE PAGES

Alliance (1)

Gene:60309 (1)

VEGA:OTTDARG00000001870 (1)

VEGA:OTTDARG00000009430 (1)

Ensembl(GRCz11):ENSDARG00000014891 (2)

ORTHOLOGY for robo2 (Chr: 15)

CITATIONS (78)

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