ZFIN ID: ZDB-GENE-001019-1
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Gene Name: roundabout, axon guidance receptor, homolog 2 (Drosophila)
Gene Symbol: robo2
Sequence Ontology ID : SO:0000704

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: ast, astray, sb:eu937, unp1881, zmp:0000000549 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 15 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Involved in several processes, including cell morphogenesis, nervous system development, and sensory perception of touch; predicted to localize to the axolemma and integral component of membrane;  ...
GENE EXPRESSION
All Expression Data: 32 figures from 20 publications
Directly Submitted Expression Data: 6 figures (5 images) from Thisse et al., 2005 [eu937]
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019390Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la019391Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • robo2_unspecified Unspecified Unknown Unknown
    sa6395 Point Mutation Unknown Splice Site ENU
    sa10275 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa14991 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa24995 Point Mutation Unknown Splice Site ENU
    sa30686 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35974 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35975 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35976 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42608 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • te284 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • te378 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • ti272z Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • tl231 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • Targeting reagents:
    PHENOTYPE
    Data: 28 figures from 13 publications
    Observed in:
    DISEASE ASSOCIATED WITH robo2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    vesicoureteral reflux Vesicoureteral reflux 2 610878
    DISEASE ASSOCIATED WITH robo2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior axon guidance (more)
    Cellular Component axolemma (more)
    Molecular Function protein binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013106 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR032985 (1)
  • InterPro:IPR032986 (1)
  • InterPro:IPR036116 (1)
  • InterPro:IPR036179 (1)
    		•
  • PROSITE:PS50835 (1)
  • PROSITE:PS50853 (1)
    		•
  • Pfam:PF00041 (1)
  • Pfam:PF07679 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ottdart00000001997 (1) 226
    Select Tool
    robo2-203 (1) 552
    Select Tool
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM robo2 No data available
    MARKER RELATIONSHIPS
    robo2Contained in: [BAC] CH211-15J21 (1) (order this)
    [Fosmid] CH1073-132M13 (1) (order this)
    [PAC] BUSM1-181A10 (1) (order this)
    robo2Encodes: [EST] eu937 (1)
    [cDNA] cssl:d829 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131633 (1) 4871bp
    Select Tool
    Genomic GenBank:BX088709 (1) 156236bp
    Select Tool
    Polypeptide UniProtKB:Q90Z70 (1) 1513aa
    Select Tool
    Sequence Clusters UniGene:83334 (1)
    Sequence Information (all 93)
    OTHER robo2 GENE PAGES
  • Alliance (1)
  • Gene:60309 (1)
  • VEGA:OTTDARG00000001870 (1)
  • VEGA:OTTDARG00000009430 (1)
  • Ensembl(GRCz11):ENSDARG00000014891 (2)
    • ORTHOLOGY for robo2 (Chr: 15)
    CITATIONS (77)