ZFIN ID: ZDB-GENE-001019-1
Gene Name: roundabout, axon guidance receptor, homolog 2 (Drosophila)
Gene Symbol: robo2    Nomenclature History

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Previous Names: ast, astray, sb:eu937, unp1881, zmp:0000000549 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Involved in cranial nerve morphogenesis; generation of neurons; and sensory perception of touch. Predicted to localize to integral component of membrane. Is expressed in several structures, including digestive system; dorsal fin; nervous system; spleen; and trigeminal placode. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2).
Genome Resources: Alliance (1),  Gene:60309 (1),  Ensembl(GRCz11):ENSDARG00000014891 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019390Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la019391Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • robo2_unspecified Unspecified Unknown Unknown
    sa6395 Point Mutation Unknown Splice Site ENU
    sa10275 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14991 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24995 Point Mutation Unknown Splice Site ENU
    sa30686 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35974 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35975 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35976 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42608 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • te284 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • te378 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ti272z Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tl231 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-robo2 N/A 1
    MO2-robo2 N/A 1
    MO3-robo2 N/A 2
    MO4-robo2 N/A 1
    MO5-robo2 N/A 2
    MO6-robo2 N/A 1
    MO7-robo2 N/A 1
    MO8-robo2 N/A 1
    DISEASE ASSOCIATED WITH robo2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    vesicoureteral reflux Alliance Vesicoureteral reflux 2 610878
    DISEASE ASSOCIATED WITH robo2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior axon guidance (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ottdart00000001997 (1) 226
    robo2-203 (1)    Ensembl 552
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM robo2 No data available
    MARKER RELATIONSHIPS
    robo2 Contained in: [BAC] CH211-15J21 (1)
    [Fosmid] CH1073-132M13 (1)
    [PAC] BUSM1-181A10 (1)
    robo2 Encodes: [EST] eu937 (1)
    [cDNA] cssl:d829 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131633 (1) 4871 nt
    Genomic GenBank:BX088709 (1) 156236 nt
    Select Tool
    Polypeptide UniProtKB:Q90Z70 (1) 1513 aa
    Sequence Information (all 92)
    ORTHOLOGY for robo2 ( Chr: 15 )
    CITATIONS (83)