ZFIN Gene: robo2

ZFIN ID: ZDB-GENE-001019-1

ZFIN ID: ZDB-GENE-001019-1

Gene Name:

roundabout, axon guidance receptor, homolog 2 (Drosophila)

Gene Symbol:

robo2 Nomenclature History

Previous Names:

ast, astray, sb:eu937, unp1881, zmp:0000000549 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 15 Mapping Details/Browsers

Description:

Involved in cranial nerve morphogenesis; generation of neurons; and sensory perception of touch. Predicted to localize to integral component of membrane. Is expressed in several structures, including digestive system; dorsal fin; nervous system; spleen; and trigeminal placode. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Orthologous to human ROBO2 (roundabout guidance receptor 2).

Genome Resources:

Alliance (1), Gene:60309 (1), Ensembl(GRCz11):ENSDARG00000014891 (2)

GENE EXPRESSION
All Expression Data:	34 figures from 22 publications
Directly Submitted Expression Data:	6 figures (5 images) from Thisse et al., 2005 [eu937]
Wild-type Stages, Structures:	Blastula:1k-cell (3.0h-3.33h) to Adult (90d-730d, breeding adult)
	brain central nervous system diencephalon dopaminergic neuron digestive system dorsal fin dorsal telencephalon ventro-lateral region dorso-rostral cluster eye forebrain gill hindbrain liver midbrain olfactory epithelium olfactory placode optic tectum primitive olfactory epithelium retinal ganglion cell retinal ganglion cell layer spleen statoacoustic (VIII) ganglion neuron trigeminal ganglion trigeminal placode unspecified ventro-caudal cluster ventro-rostral cluster whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la019390Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la019391Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
robo2_unspecified	Unspecified	Unknown	Unknown
sa6395	Point Mutation	Unknown	Splice Site	ENU
sa10275	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa14991	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa24995	Point Mutation	Unknown	Splice Site	ENU
sa30686	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35974	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35975	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35976	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa42608	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
te284	Point Mutation	Unknown	Missense	ENU	European Zebrafish Resource Center (EZRC) (order this)
te378	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)
ti272z	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this)
tl231	Unknown	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-robo2	N/A	1
MO2-robo2	N/A	1
MO3-robo2	N/A	2
MO4-robo2	N/A	1
MO5-robo2	N/A	2
MO6-robo2	N/A	1
MO7-robo2	N/A	1
MO8-robo2	N/A	1

PHENOTYPE

Data:

30 figures from 14 publications

Observed in:

DISEASE ASSOCIATED WITH robo2 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
vesicoureteral reflux	Alliance	Vesicoureteral reflux 2	610878

DISEASE ASSOCIATED WITH robo2 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	anterior/posterior axon guidance (more)
Cellular Component	integral component of membrane (more)
Molecular Function	protein binding (more)

GO Terms (all 14)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	ottdart00000001997 (1)	226	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	robo2-203 (1)	552	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: NCBI

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM robo2 No data available

MARKER RELATIONSHIPS

robo2 Contained in:	[BAC] CH211-15J21 (1) [Fosmid] CH1073-132M13 (1) [PAC] BUSM1-181A10 (1)
robo2 Encodes:	[EST] eu937 (1) [cDNA] cssl:d829 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_131633 (1)	4871 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX088709 (1)	156236 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q90Z70 (1)	1513 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 92)

ORTHOLOGY for robo2 ( Chr: 15 )

CITATIONS (83)

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