Gene

robo2

ID

ZDB-GENE-001019-1

Name

roundabout, axon guidance receptor, homolog 2 (Drosophila)

Symbol

robo2 Nomenclature History

Previous Names

ast
astray
sb:eu937
unp1881
zmp:0000000549 (1)

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Involved in cranial nerve morphogenesis; generation of neurons; and sensory perception of touch. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in vesicoureteral reflux. Is expressed in several structures, including digestive system; dorsal fin; nervous system; spleen; and trigeminal placode. Orthologous to human ROBO2 (roundabout guidance receptor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

35 figures from 23 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UCSC scRNA-seq

Thisse Expression Data

eu937 (5 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 30 figures from 14 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With robo2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
vesicoureteral reflux	Alliance	Vesicoureteral reflux 2	610878

Associated With robo2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin subtype
Domain	IPR003961	Fibronectin type III
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR013106	Immunoglobulin V-set domain
Family	IPR032986	Roundabout homologue 1
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036116	Fibronectin type III superfamily
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Fibronectin type III	Fibronectin type III superfamily	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype	Immunoglobulin subtype 2	Immunoglobulin V-set domain	Roundabout homologue 1
UniProtKB:Q1LY64 InterPro	128
UniProtKB:A0A2R8Q4U8 InterPro	136
UniProtKB:Q19S04 InterPro	111
UniProtKB:A4JYH1 InterPro	862
UniProtKB:Q804R9 InterPro	20
UniProtKB:Q90Z70 InterPro	1513
UniProtKB:Q19S05 InterPro	46
UniProtKB:F1QBD4 InterPro	1387
UniProtKB:B8K0D7 InterPro	399

Transcripts

Genome Browsers

NCBI

Type	Name	Length (nt)	Analysis
mRNA	ottdart00000001997 (1)	226 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	robo2-203 (1) Ensembl	552 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations