Gene

fech

ID
ZDB-GENE-000928-1
Name
ferrochelatase
Symbol
fech Nomenclature History
Previous Names
  • fch (1)
  • dracula
  • drc
  • frx
  • zgc:109851
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Exhibits ferrochelatase activity. Involved in erythrocyte maturation. Predicted to localize to mitochondrion. Is expressed in blood; intermediate cell mass of mesoderm; posterior lateral plate mesoderm; and ventral mesoderm. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase).
Genome Resources
Note
None
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fech Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
erythropoietic protoporphyria Alliance Protoporphyria, erythropoietic, 1 177000
Associated With fech Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR019772 Ferrochelatase, active site
Domain IPR033644 Ferrochelatase, C-terminal
Domain IPR033659 Ferrochelatase, N-terminal
Family IPR001015 Ferrochelatase
Domain Details Per Protein
Protein Length Ferrochelatase Ferrochelatase, active site Ferrochelatase, C-terminal Ferrochelatase, N-terminal
UniProtKB:F1R362 409
UniProtKB:Q568U9 409
UniProtKB:Q9DFU9 409
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations