ZFIN ID: ZDB-GENE-000928-1
Gene Name: ferrochelatase
Gene Symbol: fech    Nomenclature History

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Previous Names: fch (1), dracula, drc, frx, zgc:109851

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Exhibits ferrochelatase activity. Involved in erythrocyte maturation. Predicted to localize to mitochondrion. Is expressed in blood; intermediate cell mass of mesoderm; posterior lateral plate mesoderm; and ventral mesoderm. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase).
Genome Resources: Alliance (1),  Gene:58215 (1),  Ensembl(GRCz11):ENSDARG00000003462 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2004 [MGC:109851]
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m87 Unknown Unknown Unknown ENU
m159 Unknown Unknown Unknown ENU
m248 Point Mutation Donor Splice Site Unknown ENU
m328 Unknown Unknown Unknown ENU
sa23835 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37199 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tu271 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fech N/A 2
    MO2-fech N/A 1
    MO3-fech N/A 1
    DISEASE ASSOCIATED WITH fech HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    erythropoietic protoporphyria Alliance Protoporphyria, erythropoietic, 1 177000
    DISEASE ASSOCIATED WITH fech VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process erythrocyte maturation (more)
    Cellular Component mitochondrion (more)
    Molecular Function ferrochelatase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fech-201 (1)    Ensembl 1431
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fech No data available
    MARKER RELATIONSHIPS
    fech Contained in: [Fosmid] CH1073-334H6 (1)
    fech Encodes: [cDNA] MGC:109851 (1), MGC:191894 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131631 (1) 1405 nt
    Genomic GenBank:FP245523 (1) 34475 nt
    Select Tool
    Polypeptide UniProtKB:F1R362 (1) 409 aa
    Sequence Information (all 17)
    ORTHOLOGY for fech ( Chr: 21 )
    CITATIONS (47)