ZFIN ID: ZDB-GENE-000831-2
Gene Name: ferritin, heavy polypeptide 1a
Gene Symbol: fth1a    Nomenclature History

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Previous Names: fth1 (1), fb06g09, hm:zeh1145, wu:fb06g09, wu:fq18c10, zeh1145

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have ferric iron binding activity; ferrous iron binding activity; and ferroxidase activity. Predicted to be involved in intracellular sequestering of iron ion. Predicted to localize to cytoplasm. Is expressed in blood; eye; liver; ovary; and testis. Human ortholog(s) of this gene implicated in hemochromatosis type 5. Orthologous to several human genes including FTH1 (ferritin heavy chain 1).
Genome Resources: Alliance (1),  Gene:58108 (1),  Ensembl(GRCz11):ENSDARG00000015551 (2)
GENE EXPRESSION
All Expression Data: 11 figures from 7 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55220]
  4 figures (10 images) from Rauch et al., 2003 [fq18c10]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH fth1a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hemochromatosis type 5 Alliance ?Hemochromatosis, type 5 615517
DISEASE ASSOCIATED WITH fth1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process cellular iron ion homeostasis (more)
Cellular Component cytoplasm (more)
Molecular Function ferric iron binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA fth1a-201 (1)    Ensembl 1091
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM fth1a No data available
MARKER RELATIONSHIPS
fth1a Encodes: [EST] fb06g09, fq18c10 (1) (order this), zeh1145
[cDNA] MGC:55220 (1), MGC:191115 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131585 (1) 1062 nt
Polypeptide UniProtKB:Q9DDT0 (1) 177 aa
Sequence Information (all 25)
ORTHOLOGY for fth1a ( Chr: 7 )
CITATIONS (40)