| ZFIN ID: ZDB-GENE-000816-1 |
| Gene Name: | fibroblast growth factor receptor 3 | |||||||||||||
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| Gene Symbol: | fgfr3 Nomenclature History |
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| Previous Names: | Z-FGFR3, fc27h01, sb:eu563, wu:fc27h01 (1) | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 13 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have fibroblast growth factor binding activity and fibroblast growth factor-activated receptor activity. Involved in regulation of hematopoietic stem cell differentiation. Predicted to localize to the integral component of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in several diseases, including LADD syndrome; SADDAN; acanthosis nigricans; bone disease (multiple); and camptodactyly-tall stature-scoliosis-hearing loss syndrome. Is expressed in several structures, including cranium; integument; nervous system; neural rod; and neural tube. Orthologous to human FGFR3 (fibroblast growth factor receptor 3). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:58129 (1), Ensembl(GRCz11):ENSDARG00000004782 (1) | |||||||||||||
| Data: | Fig. S4 from Pouget et al., 2014 |
| Observed in: |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| achondroplasia | Alliance | Achondroplasia | 100800 |
| camptodactyly-tall stature-scoliosis-hearing loss syndrome | Alliance | CATSHL syndrome | 610474 |
| cervical cancer | Alliance | Cervical cancer, somatic | 603956 |
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| Crouzon syndrome-acanthosis nigricans syndrome | Alliance | Crouzon syndrome with acanthosis nigricans | 612247 |
| epidermal nevus | Alliance | Nevus, epidermal, somatic | 162900 |
| hypochondroplasia | Alliance | Hypochondroplasia | 146000 |
| LADD syndrome | Alliance | LADD syndrome | 149730 |
| Muenke Syndrome | Alliance | Muenke syndrome | 602849 |
| SADDAN | Alliance | SADDAN | 616482 |
| testicular germ cell cancer | Alliance | Spermatocytic seminoma, somatic | 273300 |
| thanatophoric dysplasia | Alliance | Thanatophoric dysplasia, type I | 187600 |
| Thanatophoric dysplasia, type II | 187601 | ||
| urinary bladder cancer | Alliance | Bladder cancer, somatic | 109800 |
| Ontology | GO Term |
|---|---|
| Biological Process | regulation of hematopoietic stem cell differentiation (more) |
| Cellular Component | integral component of membrane (more) |
| Molecular Function | ATP binding (more) |
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| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
fgfr3-202
(1)
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2999 |
Select Tool
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fgfr3-203
(1)
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3233 |
Select Tool
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
| fgfr3 Contained in: | [BAC] CH73-92M9 (1) (order this), CH211-195N12 (1) (order this), DKEY-181A13 (1) (order this) |
| fgfr3 Encodes: |
[EST]
eu563 (1),
fc27h01
[cDNA] MGC:193660 (1) (order this) |
| Type | Accession # | Length (bp/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_131606 (1) | 3002 bp |
Select Tool
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| Genomic | GenBank:CR556722 (1) | 205873 bp | Blast at MegaBLAST |
| Polypeptide | UniProtKB:F1QPA0 (1) | 819 aa |
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| Sequence Clusters | UniGene:10434 (1) |
