ZFIN ID: ZDB-GENE-000804-1
Gene Name: period circadian clock 3
Gene Symbol: per3    Nomenclature History

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Previous Name: period3 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have transcription corepressor binding activity and transcription regulatory region sequence-specific DNA binding activity. Involved in circadian regulation of gene expression and photoperiodism. Predicted to localize to the cytoplasm and nucleus. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome and advanced sleep phase syndrome 3. Is expressed in central nervous system; hematopoietic system; oocyte; red sensitive photoreceptor cell; and visual system. Orthologous to human PER3 (period circadian regulator 3).
Genome Resources: Alliance (1),  Gene:58107 (1),  Ensembl(GRCz11):ENSDARG00000010519 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa21969 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41903 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-per3
    1
    MO1-per3 N/A 1
    DISEASE ASSOCIATED WITH per3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    advanced sleep phase syndrome 3 Alliance ?Advanced sleep phase syndrome, familial, 3 616882
    DISEASE ASSOCIATED WITH per3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process circadian regulation of gene expression (more)
    Cellular Component cytoplasm (more)
    Molecular Function transcription corepressor binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000014 PAS domain
    Domain IPR013655 PAS fold-3
    Family IPR015524 Period circadian protein 3
    Domain IPR022728 Period circadian-like, C-terminal
    Homologous_superfamily IPR035965 PAS domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA per3-201 (1)    Ensembl 11018
    ncRNA ottdart00000062306 (1)    Ensembl 1120
    per3-003 (1)    Ensembl 406
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM per3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(per3:Luciferase) per3 Luciferase Danio rerio 1 13
    MARKER RELATIONSHIPS
    per3 Contained in: [BAC] CH211-138E4 (1), DKEY-264D12 (1) (order this)
    per3 Encodes: [cDNA] MGC:193569 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131584 (1) 4809 bp
    Genomic GenBank:CR762484 (1) 248134 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B3DGP6 (1) 1281 aa
    Sequence Clusters UniGene:82317 (1)
    Sequence Information (all 16)
    ORTHOLOGY for per3 ( Chr: 11 )
    CITATIONS (61)