ZFIN ID: ZDB-GENE-000627-2
Gene Name: adenosine deaminase RNA specific B1a
Gene Symbol: adarb1a    Nomenclature History

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Previous Names: ADAR2 (1), adarb1, RED1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Involved in several processes, including embryonic cranial skeleton morphogenesis; lateral line development; and neural crest cell development. Predicted to localize to cytoplasm and nucleolus. Is expressed in several structures, including ceratobranchial cartilage; fin bud; nervous system; neural plate; and pericardial region. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human ADARB1 (adenosine deaminase RNA specific B1).
Genome Resources: Alliance (1),  Gene:58134 (1),  Ensembl(GRCz11):ENSDARG00000041609 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014151Tg Transgenic Insertion Unknown Unknown DNA
sa14549 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37456 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-adarb1a N/A 1
    MO2-adarb1a N/A 1
    DISEASE ASSOCIATED WITH adarb1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neurodevelopmental disorder with hypotonia, microcephaly, and seizures 618862
    DISEASE ASSOCIATED WITH adarb1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior lateral line development (more)
    Cellular Component cytoplasm (more)
    Molecular Function adenosine deaminase activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA adarb1a-201 (1)    Ensembl 5959
    adarb1a-202 (1)    Ensembl 5944
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM adarb1a No data available
    MARKER RELATIONSHIPS
    adarb1a Contained in: [BAC] DKEY-170G11 (1) (order this)
    adarb1a Encodes: [EST] eu111 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131610 (1) 5959 nt
    Genomic GenBank:CR847870 (1) 237985 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A5WUX1 (1) 720 aa
    Sequence Information (all 28)
    ORTHOLOGY for adarb1a ( Chr: 22 )
    CITATIONS (27)