Gene
adarb1a
- ID
- ZDB-GENE-000627-2
- Name
- adenosine deaminase RNA specific B1a
- Symbol
- adarb1a Nomenclature History
- Previous Names
-
- ADAR2 (1)
- adarb1
- RED1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Involved in several processes, including embryonic cranial skeleton morphogenesis; lateral line development; and neural crest cell development. Predicted to localize to cytoplasm and nucleolus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Is expressed in several structures, including ceratobranchial cartilage; fin bud; nervous system; neural plate; and pericardial region. Orthologous to human ADARB1 (adenosine deaminase RNA specific B1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu111 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Li et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with hypotonia, microcephaly, and seizures | 618862 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | ADAR2, first double-stranded RNA binding domain | ADAR2, second double-stranded RNA binding domain | Adenosine deaminase/editase | Double-stranded RNA-binding domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M1P669
|
720 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
adarb1a-201
(1)
|
Havana | 5959 nt | |
| mRNA |
adarb1a-202
(1)
|
Havana | 5944 nt |
Interactions and Pathways
No data available
Plasmids
No data available