ZFIN ID: ZDB-GENE-000616-9
Gene Name: peripherin 2b (retinal degeneration, slow)
Gene Symbol: prph2b    Nomenclature History

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Previous Name: rds4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to be involved in visual perception. Predicted to localize to integral component of plasma membrane. Is expressed in retina. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; eye degenerative disease (multiple); and fundus albipunctatus. Orthologous to human PRPH2 (peripherin 2).
Genome Resources: Alliance (1),  Gene:559209 (1),  Ensembl(GRCz11):ENSDARG00000014840 (1)
GENE EXPRESSION
All Expression Data: Fig. 9 from Lu et al., 2019
Wild-type Stages, Structures: Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth) to Juvenile:Days 45-89 (45d-90d, 14 mm, 12 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa42120 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH prph2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    fundus albipunctatus Alliance Retinitis punctata albescens 136880
    partial central choroid dystrophy Alliance Choroidal dystrophy, central areolar 2 613105
    patterned macular dystrophy 1 Alliance Macular dystrophy, patterned, 1 169150
    retinitis pigmentosa 7 Alliance Leber congenital amaurosis 18 608133
    Retinitis pigmentosa 7 and digenic form 608133
    vitelliform macular dystrophy Alliance Macular dystrophy, vitelliform, 3 608161
    DISEASE ASSOCIATED WITH prph2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process visual perception (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prph2b-201 (1)    Ensembl 2345
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prph2b No data available
    MARKER RELATIONSHIPS
    prph2b Contained in: [BAC] CH211-239I4 (1)
    prph2b Encodes: [cDNA] MGC:73325 (1), MGC:174491 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131567 (1) 2377 nt
    Genomic GenBank:AL935294 (1) 168302 nt
    Select Tool
    Polypeptide UniProtKB:Q6PBN3 (1) 342 aa
    Sequence Information (all 14)
    ORTHOLOGY for prph2b ( Chr: 13 )
    CITATIONS (22)