Gene

apaf1

ID
ZDB-GENE-000616-4
Name
apoptotic peptidase activating factor 1
Symbol
apaf1 Nomenclature History
Previous Names
  • zgc:136543
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have ADP binding activity; ATP binding activity; and peptidase activity. Predicted to be involved in apoptotic signaling pathway; proteolysis; and regulation of apoptotic process. Predicted to localize to apoptosome. Orthologous to human APAF1 (apoptotic peptidase activating factor 1).
Genome Resources
Note
None
Expression
All Expression Data
from Jin et al., 2013
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With apaf1 Human Ortholog
No data available
Associated With apaf1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019775 WD40 repeat, conserved site
Domain IPR001315 CARD domain
Domain IPR002182 NB-ARC
Domain IPR017986 WD40-repeat-containing domain
Domain IPR037963 Apoptotic Protease-Activating Factor 1, CARD domain
Domain IPR041452 APAF-1 helical domain
Family IPR017251 Apoptotic protease-activating factor 1
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Repeat IPR001680 WD40 repeat
Repeat IPR020472 G-protein beta WD-40 repeat
Domain Details Per Protein
Protein Length APAF-1 helical domain Apoptotic protease-activating factor 1 Apoptotic Protease-Activating Factor 1, CARD domain CARD domain Death-like domain superfamily G-protein beta WD-40 repeat NB-ARC P-loop containing nucleoside triphosphate hydrolase WD40 repeat WD40 repeat, conserved site WD40-repeat-containing domain WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q1JPV6 464
UniProtKB:Q9I9H8 1261
UniProtKB:F1QQ06 465
UniProtKB:A5WVJ8 1261
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations