ZFIN ID: ZDB-GENE-000616-1
Gene Name: BCL2 associated agonist of cell death b
Gene Symbol: badb    Nomenclature History

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Previous Names: bad, fa01b12, proapoptotic BH3-only protein, wu:fa01b12, wu:fa96d04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Involved in cellular response to ionizing radiation and positive regulation of apoptotic process. Localizes to mitochondrion. Is expressed in several structures, including brain; heart; hindbrain neural plate; midbrain hindbrain boundary neural keel; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human BAD (BCL2 associated agonist of cell death).
Genome Resources: Alliance (1),  Gene:58100 (1),  Ensembl(GRCz11):ENSDARG00000054937 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
zd1005 Small Deletion Unknown Unknown TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-badb N/A 3
MO2-badb N/A 1
MO3-badb N/A 2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH badb HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH badb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process NOT   positive regulation of apoptotic process (more)
Cellular Component cytoplasm (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA badb-201 (1)    Ensembl 1238
badb-202 (1)    Ensembl 1194
badb-203 (1)    Ensembl 999
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM badb
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(rag2:mCherry-badb) rag2 badbmCherry Danio rerio 1 1
Tg(rag2:mCherry-badb_L99A) rag2 badbmCherry Danio rerio 1 1
MARKER RELATIONSHIPS
badb Contained in: [BAC] CH211-284N24, DKEY-23I12 (order this)
badb Encodes: [EST] eu145 (1), fa01b12, fa96d04 (1), ft68g02
[cDNA] MGC:114031 (1), MGC:174158 (1), MGC:192122 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001270595 (1) 1249 nt
Genomic GenBank:AL954715 (1) 195884 nt
Select Tool
Polypeptide UniProtKB:A7MCM4 (1) 147 aa
Sequence Information (all 33)
ORTHOLOGY for badb ( Chr: 7 )
CITATIONS (52)