ZFIN ID: ZDB-GENE-000607-82
Gene Name: WW domain containing E3 ubiquitin protein ligase 2
Gene Symbol: wwp2
Sequence Ontology ID : SO:0000704

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Previous Names: id:ibd1121, wu:fo87e10, zgc:154036

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(Including Attributions)
Location: Chr: 25 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have ubiquitin protein ligase activity; involved in roof of mouth development; predicted to localize to the cytoplasm and nucleus; orthologous to human WWP2 (WW domain containing E3  ...
GENE EXPRESSION
All Expression Data: 4 figures from 3 publications
Directly Submitted Expression Data: 2 figures (2 images) from Kudoh et al., 2001 [ibd1121]
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa19371 Point Mutation Unknown Splice Site ENU
sa44346 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: Fig. 2 from Nakamura et al., 2011
    Observed in:
    DISEASE ASSOCIATED WITH wwp2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH wwp2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process roof of mouth development (more)
    Cellular Component nucleus (more)
    Molecular Function ligase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000008 (1)
  • InterPro:IPR000569 (1)
  • InterPro:IPR001202 (1)
  • InterPro:IPR024928 (1)
  • InterPro:IPR035892 (1)
  • InterPro:IPR035983 (1)
  • InterPro:IPR036020 (1)
  • PROSITE:PS01159 (1)
  • PROSITE:PS50020 (1)
  • PROSITE:PS50237 (1)
  • Pfam:PF00168 (1)
  • Pfam:PF00397 (1)
  • Pfam:PF00632 (1)
  • EC:2.3.2.26 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA wwp2-004 (1) 491
    mRNA wwp2-202 (1) 5191
    wwp2-203 (1) 615
    wwp2-204 (1) 900
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM wwp2 No data available
    MARKER RELATIONSHIPS
    wwp2Contained in: [BAC] DKEYP-7F1 (1)
    wwp2Encodes: [EST] fo87e10, ibd1121 (order this)
    [cDNA] MGC:154036 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001099448 (1) 5075bp
    Genomic GenBank:BX890570 (1) 170260bp
    Select Tool
    Polypeptide UniProtKB:F6P346 (1) 867aa
    Sequence Clusters UniGene:78595 (1)
    Sequence Information (all 27)
    OTHER wwp2 GENE PAGES
  • Alliance (1)
  • Gene:564527 (1)
  • VEGA:OTTDARG00000028479 (1)
  • Ensembl(GRCz11):ENSDARG00000061345 (2)
  • ORTHOLOGY for wwp2 (Chr: 25)
    CITATIONS (25)