Gene
sox5
- ID
- ZDB-GENE-000607-13
- Name
- SRY-box transcription factor 5
- Symbol
- sox5 Nomenclature History
- Previous Names
-
- sox5b (1)
- id:ibd5067
- sb:eu456
- si:dkey-215a8.1
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within with a negative effect on iridophore differentiation; melanocyte differentiation; and xanthophore differentiation. Predicted to be active in nucleus. Is expressed in several structures, including brain; digestive system; fin; forebrain neural keel; and gonad. Orthologous to human SOX5 (SRY-box transcription factor 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 9 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu456 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Nagao et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| i300 | unknown | Unknown | Unknown | zinc finger nuclease | |
| i301 | unknown | Unknown | Unknown | zinc finger nuclease | |
| la011378Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la015343Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la015344Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la015345Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024453Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024454Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028982Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028983Tg | Transgenic insertion | Unknown | Unknown | DNA |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-sox5 | (2) | |
| CRISPR2-sox5 | Zebrafish Nomenclature Committee |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Lamb-Shaffer syndrome | 616803 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | High mobility group box domain | High mobility group box domain superfamily | SOX/SOX-like transcription factors |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q0P1 | InterPro | 735 | |||
| UniProtKB:A0A8M9PUN3 | InterPro | 759 | |||
| UniProtKB:A0A8M2BBY9 | InterPro | 731 | |||
| UniProtKB:A0A8M2BC41 | InterPro | 758 | |||
| UniProtKB:Q3ZM07 | InterPro | 759 | |||
| UniProtKB:A0A8M9QBE2 | InterPro | 762 | |||
| UniProtKB:A0A8M9Q0N4 | InterPro | 763 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-47D3 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-215A8 | ZFIN Curated Data | |
| Encodes | EST | eu456 | Thisse et al., 2005 | |
| Encodes | EST | ibd5067 | ||
| Encodes | cDNA | MGC:194960 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001033585 (1) | 2393 nt | ||
| Genomic | GenBank:BX547928 (1) | 228177 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q0N4 (1) | 763 aa |
- Zhu, M., Li, Y., Shen, Q., Gong, Z., Liu, D. (2024) Sex disparity in zebrafish liver cell proliferation after partial hepatectomy is regulated by sex hormone receptors and the S100A1-YAP signaling cascade. Disease models & mechanisms. 17(10):
- Tian, Y., Wang, W., Lautrup, S., Zhao, H., Li, X., Law, P.W.N., Dinh, N.D., Fang, E.F., Cheung, H.H., Chan, W.Y. (2022) WRN promotes bone development and growth by unwinding SHOX-G-quadruplexes via its helicase activity in Werner Syndrome. Nature communications. 13:5456
- Hoffmann, S., Roeth, R., Diebold, S., Gogel, J., Hassel, D., Just, S., Rappold, G.A. (2021) Identification and Tissue-Specific Characterization of Novel SHOX-Regulated Genes in Zebrafish Highlights SOX Family Members Among Other Genes. Frontiers in genetics. 12:688808
- Scott, K., O'Rourke, R., Winkler, C.C., Kearns, C.A., Appel, B. (2021) Temporal single-cell transcriptomes of zebrafish spinal cord pMN progenitors reveal distinct neuronal and glial progenitor populations. Developmental Biology. 479:37-50
- Zafar, I., Iftikhar, R., Ahmad, S.U., Rather, M.A. (2021) Genome wide identification, phylogeny, and synteny analysis of sox gene family in common carp (Cyprinus carpio). Biotechnology reports (Amsterdam, Netherlands). 30:e00607
- Huang, X., Wu, C., Gong, K., Chen, Q., Gu, Q., Qin, H., Zhao, C., Yu, T., Yang, L., Fu, W., Wang, Y., Qin, Q., Liu, S. (2020) Sox Gene Family Revealed Genetic Variations in Autotetraploid Carassius auratus. Frontiers in genetics. 11:804
- Lewis, V.M., Saunders, L.M., Larson, T.A., Bain, E.J., Sturiale, S.L., Gur, D., Chowdhury, S., Flynn, J.D., Allen, M.C., Deheyn, D.D., Lee, J.C., Simon, J.A., Lippincott-Schwartz, J., Raible, D.W., Parichy, D.M. (2019) Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Proceedings of the National Academy of Sciences of the United States of America. 116(24):11806-11811
- Safian, D., Bogerd, J., Schulz, R.W. (2019) Regulation of spermatogonial development by Fsh: the complementary roles of locally produced Igf and Wnt signaling molecules in adult zebrafish testis. General and comparative endocrinology. 284:113244
- Nagao, Y., Takada, H., Miyadai, M., Adachi, T., Seki, R., Kamei, Y., Hara, I., Taniguchi, Y., Naruse, K., Hibi, M., Kelsh, R.N., Hashimoto, H. (2018) Distinct interactions of Sox5 and Sox10 in fate specification of pigment cells in medaka and zebrafish. PLoS Genetics. 14:e1007260
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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