ZFIN Gene: pcdh18a

ZFIN ID: ZDB-GENE-000607-1

ZFIN ID: ZDB-GENE-000607-1

Gene Name:

protocadherin 18a

Gene Symbol:

pcdh18a Nomenclature History

Previous Name:

id:ibd5114 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 1 Mapping Details/Browsers

Description:

Predicted to have calcium ion binding activity. Involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell migration involved in gastrulation; and epiboly involved in gastrulation with mouth forming second. Localizes to plasma membrane. Is expressed in several structures, including axis; epiblast; midbrain neural keel; nervous system; and spinal cord neural rod. Orthologous to human PCDH18 (protocadherin 18).

Genome Resources:

Alliance (1), Gene:572532 (1), Ensembl(GRCz11):ENSDARG00000089805 (2)

GENE EXPRESSION
All Expression Data:	6 figures from 4 publications
Directly Submitted Expression Data:	2 figures (3 images) from Kudoh et al., 2001 [ibd5114]
Wild-type Stages, Structures:	Blastula:30%-epiboly (4.66h-5.25h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	anatomical structure axis diencephalon epiblast hindbrain midbrain midbrain neural keel neural crest optic tectum otic vesicle pectoral fin pectoral fin bud pharyngeal arch 3-7 prechordal plate primary neuron primary neuron hindbrain spinal cord spinal cord neural rod telencephalon thalamus whole organism
High Throughput Expression:	GEO (1) Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa9402	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa10805	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa32619	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa45066	Point Mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this)
zko275a	Indel	Unknown	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)
zko275b	Small Deletion	Unknown	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-pcdh18a	zko275a zko275b	1
MO1-pcdh18a	N/A	1
MO2-pcdh18a	N/A	2

PHENOTYPE

Data:	2 figures from Aamar et al., 2008
Observed in:	axis calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules epiboly involved in gastrulation with mouth forming second somite somitogenesis

DISEASE ASSOCIATED WITH pcdh18a HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH pcdh18a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (more)
Cellular Component	plasma membrane (more)
Molecular Function	calcium ion binding (more)

GO Terms (all 11)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS No data available

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM pcdh18a No data available

MARKER RELATIONSHIPS

pcdh18a Encodes:

[EST] ibd5114

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001115058 (1)	4443 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Polypeptide	UniProtKB:F1QRP2 (1)	1135 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 20)

ORTHOLOGY for pcdh18a ( Chr: 1 )

CITATIONS (24)

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