ZFIN ID: ZDB-GENE-000605-2
Gene Name: RUNX family transcription factor 3
Gene Symbol: runx3    Nomenclature History

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Previous Name: runxb

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in cartilage development; embryonic viscerocranium morphogenesis; and hemopoiesis. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in breast cancer (multiple); endometrial carcinoma; in situ carcinoma; pancreatic cancer; and urinary bladder cancer. Is expressed in several structures, including Rohon-Beard neurons; digestive system; ganglia; oral epithelium; and skeletal element. Orthologous to human RUNX3 (RUNX family transcription factor 3).
Genome Resources: Alliance (1),  Gene:58127 (1),  Ensembl(GRCz11):ENSDARG00000052826 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018665Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • w144 Small Deletion Exon 3 Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-runx3 1
    MO1-runx3 N/A 4
    MO2-runx3 N/A 1
    DISEASE ASSOCIATED WITH runx3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH runx3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage development (more)
    Cellular Component nucleus (more)
    Molecular Function ATP binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
    Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
    Homologous_superfamily IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamily
    Domain IPR013524 Runt domain
    Domain IPR013711 Runx, C-terminal domain
    Family IPR016554 Runt-related transcription factor RUNX
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA runx3-202 (1)    Ensembl 5881
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM runx3 No data available
    MARKER RELATIONSHIPS
    runx3 Contained in: [BAC] DKEY-84B12 (1) (order this)
    runx3 Encodes: [EST] IMAGE:7154002 (1)
    [cDNA] MGC:195110 (1), MGC:195118 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131604 (1) 6115 bp
    Genomic GenBank:CT025744 (1) 59862 bp
    Select Tool
    Polypeptide UniProtKB:A0A3S6CNL9 (1) 438 aa
    Sequence Information (all 56)
    ORTHOLOGY for runx3 ( Chr: 13 )
    CITATIONS (50)