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Gene

runx3

ID
ZDB-GENE-000605-2
Name
RUNX family transcription factor 3
Symbol
runx3 Nomenclature History
Previous Names
  • runxb
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cartilage development; embryonic viscerocranium morphogenesis; and hemopoiesis. Predicted to be located in nucleus. Is expressed in several structures, including Rohon-Beard neurons; digestive system; ganglia; oral epithelium; and skeletal element. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); female reproductive organ cancer (multiple); lung non-small cell carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With runx3 Human Ortholog
No data available
Associated With runx3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013524 Runt domain
Domain IPR013711 Runx, C-terminal domain
Family IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
Family IPR016554 Runt-related transcription factor RUNX
Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
Homologous_superfamily IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Acute myeloid leukemia 1 protein (AML1)/Runt p53-like transcription factor, DNA-binding p53/RUNT-type transcription factor, DNA-binding domain superfamily Runt domain Runt-related transcription factor RUNX Runx, C-terminal domain
UniProtKB:Q9DD59 438
UniProtKB:A0A3S6CNL9 438
UniProtKB:A0A3S6D6Y9 157
UniProtKB:A0A3S7HNZ6 385
UniProtKB:A0A3S6CT15 192
UniProtKB:Q9DGB7 424
UniProtKB:A0A3S6CWH5 347
UniProtKB:F6NM27 438
UniProtKB:A0A3S6CQ91 269
UniProtKB:A0A3S6CZJ1 303
UniProtKB:Q9DEA0 424
UniProtKB:F1QZI1 250
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations