Gene

hand2

ID
ZDB-GENE-000511-1
Name
heart and neural crest derivatives expressed 2
Symbol
hand2 Nomenclature History
Previous Names
  • dhand (1)
  • han
  • zdHAND (1)
  • hands off
  • zgc:103415
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; determination of intestine left/right asymmetry; and nervous system development. Predicted to localize to nucleus. Is expressed in several structures, including cardiovascular system; digestive system; head; mesoderm; and pectoral fin. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2).
Genome Resources
Note
None
Expression
All Expression Data
154 figures from 105 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
16 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hand2 Human Ortholog
No data available
Associated With hand2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:P57102 208
UniProtKB:A2BDM6 205
UniProtKB:Q5XJD8 208
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations