ZFIN ID: ZDB-GENE-000502-1
Gene Name: bone morphogenetic protein receptor, type IAa
Gene Symbol: bmpr1aa
Previous Names: alk3a (1), bmpr1a, BR1a, zBMPR-IA (1), alk3 (1), alk3tr, zgc:136731
Location: Chr: 13   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 6 figures from 5 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  blastoderm, blastodisc, epiblast, hypoblast (all 9) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 7 Genotypes
Knockdown reagents: MO1-bmpr1aa (1)

Allele Type Mutagen Suppliers
hu4087 Point Mutation ENU
la010910Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la011473Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018458Tg Transgenic Insertion DNA
    la027404Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: 3 figures from 2 publications
    Observed in: blood island, determination of digestive tract left/right asymmetry, dorsal/ventral pattern formation, embryonic heart tube left/right pattern formation (all 15) expand

    Phenotype of Human Orthologue OMIM Phenotype ID
    Juvenile polyposis syndrome, infantile form 174900
    Polyposis syndrome, hereditary mixed, 2 610069
    Polyposis, juvenile intestinal 174900
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein homooligomerization (more)
    Cellular Component BMP receptor complex (more)
    Molecular Function protein binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000333 (1)
  • InterPro:IPR000472 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR003605 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS51256 (1)
  • Pfam:PF00069 (1)
  • Pfam:PF01064 (1)
  • Pfam:PF08515 (1)
  • EC:2.7.11.30 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA bmpr1aa-001 (1) 4147
    ncRNA bmpr1aa-002 (1) 474
    bmpr1aa-003 (1) 713
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bmpr1aa
    Tg(col2a1a:bmpr1aa), Tg(Ola.Sp7:bmpr1aa), Tg(Ola.Sp7:dnbmpr1aa), Tg(UAS:bmpr1aa,myl7:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    bmpr1aa Contained in: [BAC] CH211-134M17 (1) (order this), DKEY-230G10 (1) (order this)
    bmpr1aa Encodes: [cDNA] MGC:136731 (1) (order this), MGC:194991 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131621 (1) 4159 bp
    Genomic GenBank:BX005174 (1) 178371 bp
    Select Tool
    Polypeptide UniProtKB:O93243 (1) 527 aa
    Sequence Clusters UniGene:78292 (1)
    Sequence Information (all 22)
    OTHER bmpr1aa GENE PAGES
  • Gene:58145 (1)
  • VEGA:OTTDARG00000029634 (1)
  • Ensembl(Zv9):ENSDARG00000019728 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish bmpr1aa 13  
    Human BMPR1A 10 (10q22.3)
  • OMIM:601299
  • Gene:657
  • Mouse Bmpr1a 14 ( 20.81 cM)
  • MGI:1338938
  • Gene:12166
  • Orthology Details
    CITATIONS (45)