Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-000502-1
Gene Name: bone morphogenetic protein receptor, type 1aa
Gene Symbol: bmpr1aa
Previous Names: alk3a (1), bmpr1a, BR1a, zBMPR-IA (1), alk3 (1), alk3tr, zgc:136731
Nomenclature History
GENE EXPRESSION
All Expression Data: 6 figures from 5 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  blastoderm, blastodisc, epiblast, hypoblast (all 9) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 7 genotypes
Alleles: hu4087, la010910Tg, la011473Tg, la018458Tg, la027404Tg
Knockdown reagents: MO1-bmpr1aa (1)
PHENOTYPE
Data: 3 figures from 2 publications
Observed in: blood island, determination of digestive tract left/right asymmetry, dorsal/ventral pattern formation, embryonic heart tube left/right pattern formation (all 15) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Juvenile polyposis syndrome, infantile form 174900
Polyposis syndrome, hereditary mixed, 2 610069
Polyposis, juvenile intestinal 174900
GENE ONTOLOGY
Ontology GO Term
Biological Process protein homooligomerization (more)
Cellular Component BMP receptor complex (more)
Molecular Function protein binding (more)
GO Terms (all 21)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000472 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR003605 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS51256 (1)
  • Pfam:PF00069 (1)
  • Pfam:PF01064 (1)
  • Pfam:PF08515 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA bmpr1aa-001 (1) 4147
    ncRNA bmpr1aa-002 (1) 474
    bmpr1aa-003 (1) 713
    GENE PRODUCT DESCRIPTION No description available
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM bmpr1aa
    Tg(col2a1a:bmpr1aa), Tg(Ola.Sp7:bmpr1aa), Tg(Ola.Sp7:dnbmpr1aa), Tg(UAS:bmpr1aa,myl7:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    bmpr1aa Contained in: [BAC] CH211-134M17 (1) (order this), DKEY-230G10 (1)
    bmpr1aa Encodes: [cDNA] MGC:136731 (1) (order this), MGC:194991 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131621 (1) 4159 bp
    Genomic GenBank:BX005174 (1) 178371 bp
    Select Tool
    Polypeptide UniProtKB:O93243 (1) 527 aa
    Sequence Clusters UniGene:78292 (1)
    Sequence Information (all 20)
    OTHER bmpr1aa GENE PAGES
  • Gene:58145 (1)
  • VEGA:OTTDARG00000029634 (1)
  • Ensembl(Zv9):ENSDARG00000019728 (1)
  • MAPPING INFORMATION
    Chr: 13 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish bmpr1aa 13  
    Human BMPR1A 10 (10q22.3)
  • OMIM:601299
  • Gene:657
  • Mouse Bmpr1a 14 ( 20.81 cM)
  • MGI:1338938
  • Gene:12166
  • CITATIONS (40)