Gene

bmpr1aa

ID
ZDB-GENE-000502-1
Name
bone morphogenetic protein receptor, type IAa
Symbol
bmpr1aa Nomenclature History
Previous Names
  • alk3a (1)
  • bmpr1a
  • BR1a
  • zBMPR-IA (1)
  • alk3 (1)
  • alk3tr
  • zgc:136731
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have SMAD binding activity and transforming growth factor beta receptor activity, type I. Involved in BMP signaling pathway; circulatory system development; and dorsal/ventral pattern formation. Localizes to BMP receptor complex. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Is expressed in several structures, including blastoderm; digestive system; germ ring; ovarian follicle; and posterior cardinal vein. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
13 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bmpr1aa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary mixed polyposis syndrome 2 Alliance Polyposis syndrome, hereditary mixed, 2 610069
juvenile polyposis syndrome Alliance Polyposis, juvenile intestinal 174900
Associated With bmpr1aa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000472 Activin types I and II receptor domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003605 GS domain
Family IPR000333 Ser/Thr protein kinase, TGFB receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Activin types I and II receptor domain GS domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine-threonine/tyrosine-protein kinase, catalytic domain Ser/Thr protein kinase, TGFB receptor
UniProtKB:Q1RLX1 527
UniProtKB:O93243 527
UniProtKB:B3DJG0 526
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations