ZFIN ID: ZDB-GENE-000502-1
Gene Name: bone morphogenetic protein receptor, type IAa
Gene Symbol: bmpr1aa    Nomenclature History

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Previous Names: alk3a (1), bmpr1a, BR1a, zBMPR-IA (1), alk3 (1), alk3tr, zgc:136731

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have SMAD binding activity and transforming growth factor beta receptor activity, type I. Involved in circulatory system development; dorsal/ventral pattern formation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to BMP receptor complex. Is expressed in several structures, including blastoderm; digestive system; germ ring; ovarian follicle; and posterior cardinal vein. Human ortholog(s) of this gene implicated in hereditary mixed polyposis syndrome 2; intestinal disease; and juvenile polyposis syndrome. Orthologous to human BMPR1A (bone morphogenetic protein receptor type 1A).
Genome Resources: Alliance (1),  Gene:58145 (1),  Ensembl(GRCz11):ENSDARG00000019728 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu4087 Point Mutation Unknown Missense ENU
la010910Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la011473Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018458Tg Transgenic Insertion Unknown Unknown DNA
    la027404Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8457 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44785 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bmpr1aa N/A 5
    DISEASE ASSOCIATED WITH bmpr1aa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary mixed polyposis syndrome 2 Alliance Polyposis syndrome, hereditary mixed, 2 610069
    juvenile polyposis syndrome Alliance Juvenile polyposis syndrome, infantile form 174900
    Polyposis, juvenile intestinal 174900
    DISEASE ASSOCIATED WITH bmpr1aa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process BMP signaling pathway (more)
    Cellular Component BMP receptor complex (more)
    Molecular Function protein binding (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bmpr1aa-201 (1)    Ensembl 4147
    ncRNA bmpr1aa-002 (1)    Ensembl 474
    bmpr1aa-003 (1)    Ensembl 713
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bmpr1aa
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(5xuas:cabmpr1aa-ha) UAS bmpr1aaHA Danio rerio 1 1
    Tg(col2a1a:bmpr1aa) col2a1a bmpr1aa Danio rerio 1 2
    Tg(Ola.Sp7:bmpr1aa) bmpr1aa Danio rerioOryzias latipes 1 2
    Tg(Ola.Sp7:dnbmpr1aa) bmpr1aa Danio rerioOryzias latipes 1 2
    Tg(UAS:bmpr1aa,myl7:EGFP) myl7 bmpr1aaEGFP Danio rerio 1 3
    tg(uas:bmpr1aa-ires-egfp) UAS bmpr1aaEGFPIRES Danio rerio 2 1
    tg(uas:bmpr1aa_r438h-ires-egfp) UAS bmpr1aaEGFPIRES Danio rerio 3 1
    Tg(UAS:dnbmpr1aa-UTRnanos3) UAS bmpr1aananos3UTR Danio rerio 1 1
    MARKER RELATIONSHIPS
    bmpr1aa Contained in: [BAC] CH211-134M17 (1), DKEY-230G10 (1) (order this)
    bmpr1aa Encodes: [cDNA] MGC:136731 (1), MGC:194991 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131621 (1) 2494 nt
    Genomic GenBank:BX005174 (1) 178371 nt
    Select Tool
    Polypeptide UniProtKB:O93243 (1) 527 aa
    Sequence Information (all 28)
    ORTHOLOGY for bmpr1aa ( Chr: 13 )
    CITATIONS (71)