ZFIN ID: ZDB-GENE-000405-1
Gene Name: pre-B-cell leukemia homeobox 1a
Gene Symbol: pbx1a    Nomenclature History

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Previous Names: pbx1b (1), fi29e01, wu:fi29e01 (1), zgc:55265 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in hemopoiesis; swim bladder morphogenesis; and vasculature development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in precursor B lymphoblastic lymphoma/leukemia. Is expressed in several structures, including central nervous system; head; pleuroperitoneal region; presumptive swim bladder; and swim bladder bud. Orthologous to human PBX1 (PBX homeobox 1).
Genome Resources: Alliance (1),  Gene:58138 (1),  Ensembl(GRCz11):ENSDARG00000100494 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mn0016Gt Transgenic Insertion Unknown Unknown DNA
sa12947 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14134 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15504 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17065 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31272 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32888 Point Mutation Unknown Missense, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pbx1a N/A 1
    MO2-pbx1a N/A 1
    MO3-pbx1a N/A 1
    DISEASE ASSOCIATED WITH pbx1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay 617641
    DISEASE ASSOCIATED WITH pbx1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process definitive hemopoiesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001356 Homeobox domain
    Domain IPR005542 PBX
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    Conserved_site IPR017970 Homeobox, conserved site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pbx1a-202 (1)    Ensembl 6743
    ncRNA pbx1a-002 (1)    Ensembl 1654
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pbx1a No data available
    MARKER RELATIONSHIPS
    pbx1a Contained in: [BAC] CH73-250E21 (1), CH211-174E12 (1)
    pbx1a Encodes: [EST] eu391 (1)
    [cDNA] MGC:76852 (1)
    pbx1a Is Hybridized by: [EST] fi29e01
    [cDNA] MGC:55265
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131614 (1) 2045 bp
    Genomic GenBank:CU467620 (1) 133866 bp
    Select Tool
    Polypeptide UniProtKB:Q9I9B7 (1) 428 aa
    Sequence Information (all 28)
    ORTHOLOGY for pbx1a ( Chr: 2 )
    CITATIONS (37)