Gene

pbx1a

ID
ZDB-GENE-000405-1
Name
pre-B-cell leukemia homeobox 1a
Symbol
pbx1a Nomenclature History
Previous Names
  • pbx1b (1)
  • fi29e01
  • wu:fi29e01 (1)
  • zgc:55265 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in animal organ development; neuron development; and regulation of transcription by RNA polymerase II. Acts upstream of or within hemopoiesis; swim bladder morphogenesis; and vasculature development. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; head; pleuroperitoneal region; presumptive swim bladder; and swim bladder bud. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma. Orthologous to human PBX1 (PBX homeobox 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
15 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pbx1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay Alliance Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay 617641
Associated With pbx1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR005542 PBX
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily PBX
UniProtKB:Q7ZW49 102
UniProtKB:Q9I9B7 428
UniProtKB:Q9I9B6 346
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations