ZFIN ID: ZDB-GENE-000330-5
Gene Name: cell division cycle 25B
Gene Symbol: cdc25b    Nomenclature History

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Previous Names: cdc25, cdc25a (1), sb:cb317, sds, standstill

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have protein tyrosine phosphatase activity. Involved in positive regulation of mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle; and regulation of mitotic cell cycle, embryonic. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including DEL; anterior neural keel; axis; nervous system; and optic vesicle. Human ortholog(s) of this gene implicated in autosomal recessive polycystic kidney disease; cervical cancer; endometrial cancer; prostate cancer; and urinary bladder cancer. Orthologous to several human genes including CDC25B (cell division cycle 25B).
Genome Resources: Alliance (1),  Gene:57925 (1),  Ensembl(GRCz11):ENSDARG00000010792 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cz319 Point Mutation Unknown Premature Stop ENU
la012281Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la012282Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018401Tg Transgenic Insertion Unknown Unknown DNA
    la018403Tg Transgenic Insertion Unknown Unknown DNA
    sa42162 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42163 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cdc25b N/A 1
    MO2-cdc25b N/A 1
    DISEASE ASSOCIATED WITH cdc25b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cdc25b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of mitotic cell cycle (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein tyrosine phosphatase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdc25b-201 (1)    Ensembl 3104
    cdc25b-202 (1)    Ensembl 412
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cdc25b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:cdc25b-2A-Venus) hsp70l 2Acdc25bVenus Danio rerio 1 2
    Tg(hsp70l:cdc25b_S213A_S305A_T564A-2A-Venus) hsp70l 2Acdc25bVenus Danio rerio 1 3
    MARKER RELATIONSHIPS
    cdc25b Contained in: [BAC] DKEY-146D24 (1) (order this), DKEY-159C24 (1) (order this)
    cdc25b Encodes: [EST] cb317 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001115095 (1) 3110 nt
    Genomic GenBank:BX571943 (1) 193538 nt
    Select Tool
    Polypeptide UniProtKB:B8A5N7 (1) 563 aa
    Sequence Information (all 19)
    ORTHOLOGY for cdc25b ( Chr: 13 )
    CITATIONS (42)