ZFIN ID: ZDB-GENE-000330-4
Gene Name: syntaxin 1B
Gene Symbol: stx1b    Nomenclature History

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Previous Names: fb76h10, syntaxin1b, wu:fb76h10, zgc:92909

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have SNAP receptor activity and SNARE binding activity. Involved in regulation of synaptic activity. Predicted to localize to several cellular components, including the SNARE complex; presynaptic active zone membrane; and synaptic vesicle. Used to study epilepsy. Human ortholog(s) of this gene implicated in generalized epilepsy with febrile seizures plus 9. Is expressed in nervous system and trigeminal placode. Orthologous to human STX1B (syntaxin 1B).
Genome Resources: Alliance (1),  Gene:58038 (1),  Ensembl(GRCz11):ENSDARG00000000503 (2)
GENE EXPRESSION
All Expression Data: 10 figures from 2 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2004 [MGC:92909]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013531Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la020924Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028080Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17797 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-stx1b N/A 3
    MO2-stx1b N/A 2
    DISEASE ASSOCIATED WITH stx1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    generalized epilepsy with febrile seizures plus 9 Alliance Generalized epilepsy with febrile seizures plus, type 9 616172
    DISEASE ASSOCIATED WITH stx1b VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    epilepsy AB + MO1-stx1b standard conditions Hunyadi et al., 2017
    AB + MO1-stx1b + MO2-stx1b standard conditions Schubert et al., 2014
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of synaptic activity (more)
    Cellular Component integral component of membrane (more)
    Molecular Function SNAP receptor activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR006012 Syntaxin/epimorphin, conserved site
    Domain IPR000727 Target SNARE coiled-coil homology domain
    Domain IPR006011 Syntaxin, N-terminal domain
    Family IPR028669 Syntaxin 1
    Homologous_superfamily IPR010989 SNARE
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA stx1b-201 (1)    Ensembl 6818
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM stx1b No data available
    MARKER RELATIONSHIPS
    stx1b Contained in: [BAC] DKEY-89B17 (1) (order this)
    stx1b Encodes: [EST] fb76h10
    [cDNA] MGC:92909 (1), MGC:192230 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131523 (1) 867 nt
    Genomic GenBank:AL772314 (1) 185640 nt
    Select Tool
    Polypeptide UniProtKB:Q1MTI1 (1) 288 aa
    Sequence Information (all 20)
    ORTHOLOGY for stx1b ( Chr: 19 )
    CITATIONS (29)