ZFIN ID: ZDB-GENE-000329-5
Gene Name: notch receptor 3
Gene Symbol: notch3    Nomenclature History

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Previous Names: notch5, fa14b08, wu:fa14b08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity and signaling receptor activity. Involved in several processes, including animal organ development; blood vessel development; and neurogenesis. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Is expressed in several structures, including digestive system; mesoderm; nervous system; pronephros; and vasculature. Orthologous to human NOTCH3 (notch receptor 3).
Genome Resources: Alliance (1),  Gene:58066 (1),  Ensembl(GRCz11):ENSDARG00000052139 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh332 Point Mutation Unknown Premature Stop ENU
  • China Zebrafish Resource Center (CZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • fh334 Point Mutation Unknown Unknown ENU
    la010071Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la015265Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la024295Tg Transgenic Insertion Unknown Unknown DNA
    la028945Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • notch3_unrecovered Point Mutation Unknown Unknown ENU
    sa14943 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16743 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20147 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33320 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33321 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40169 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • st51 Point Mutation Unknown Splice Site
    zm197263Tg Transgenic Insertion 5' UTR Unknown DNA
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-notch3 N/A 15
    MO2-notch3 N/A 3
    MO3-notch3 N/A 3
    MO4-notch3 N/A 1
    MO5-notch3 N/A 3
    MO6-notch3 N/A 3
    MO7-notch3 N/A 1
    DISEASE ASSOCIATED WITH notch3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    CADASIL 1 Alliance Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1 125310
    infantile myofibromatosis Alliance ?Myofibromatosis, infantile 2 615293
    lateral meningocele syndrome Alliance Lateral meningocele syndrome 130720
    DISEASE ASSOCIATED WITH notch3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal aorta development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 31)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Domain IPR000742 EGF-like domain
    Domain IPR000800 Notch domain
    Domain IPR001881 EGF-like calcium-binding domain
    Repeat IPR002110 Ankyrin repeat
    Family IPR008297 Notch
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Domain IPR010660 Notch, NOD domain
    Domain IPR011656 Notch, NODP domain
    Conserved_site IPR013032 EGF-like, conserved site
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    Domain IPR020683 Ankyrin repeat-containing domain
    Family IPR022331 Neurogenic locus Notch 3
    Domain IPR024600 Domain of unknown function DUF3454, notch
    Homologous_superfamily IPR035993 Notch-like domain superfamily
    Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA notch3-201 (1)    Ensembl 7921
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM notch3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:canotch3-EGFP) hsp70l EGFPnotch3 Danio rerio 1 6
    Tg(hsp70l:dnnotch3-EGFP) hsp70l EGFPnotch3 Danio rerio 1 3
    MARKER RELATIONSHIPS
    notch3 Contained in: [BAC] CH211-69E21 (1), DKEY-18G4 (1) (order this)
    notch3 Encodes: [EST] fa14b08
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131549 (1) 7931 bp
    Genomic GenBank:BX119930 186318 bp
    Select Tool
    Polypeptide UniProtKB:F1QZF2 (1) 2468 aa
    Sequence Information (all 18)
    ORTHOLOGY for notch3 ( Chr: 3 )
    CITATIONS (193)