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Gene

notch3

ID
ZDB-GENE-000329-5
Name
notch receptor 3
Symbol
notch3 Nomenclature History
Previous Names
  • notch5
  • fa14b08
  • wu:fa14b08
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable Notch binding activity. Acts upstream of or within several processes, including animal organ development; blood vessel development; and neurogenesis. Predicted to be located in nucleus and plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including digestive system; mesoderm; nervous system; pleuroperitoneal region; and vasculature. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (notch receptor 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
101 figures from 83 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
21 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With notch3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
CADASIL 1 Alliance Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1 125310
infantile myofibromatosis Alliance ?Myofibromatosis, infantile 2 615293
lateral meningocele syndrome Alliance Lateral meningocele syndrome 130720
Associated With notch3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000800 Notch domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR010660 Notch, NOD domain
Domain IPR011656 Notch, NODP domain
Domain IPR020683 Ankyrin repeat-containing domain
Domain IPR024600 Domain of unknown function DUF3454, notch
Family IPR008297 Notch
Family IPR022331 Neurogenic locus Notch 3
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR035993 Notch-like domain superfamily
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily Domain of unknown function DUF3454, notch EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Neurogenic locus Notch 3 Notch Notch domain Notch-like domain superfamily Notch, NOD domain Notch, NODP domain
UniProtKB:F1QZF2 2468
UniProtKB:Q800E4 2468
UniProtKB:O42373 762
UniProtKB:O93618 703
UniProtKB:A0A2R8Q5T2 704
UniProtKB:A0A2R8QH43 2417
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations