ZFIN ID: ZDB-GENE-000328-3
Gene Name: frizzled class receptor 8a
Gene Symbol: fzd8a    Nomenclature History

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Previous Names: fz5, fz8a, fzc, wu:fd02c05, zfzc, zg05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in canonical Wnt signaling pathway; eye field cell fate commitment involved in camera-type eye formation; and neurogenesis. Predicted to localize to integral component of membrane and plasma membrane. Is expressed in several structures, including digestive system; mesoderm; nervous system; neural keel; and pectoral fin. Orthologous to human FZD8 (frizzled class receptor 8).
Genome Resources: Alliance (1),  Gene:58073 (1),  Ensembl(GRCz11):ENSDARG00000045444 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa5986 Point Mutation Unknown Premature Stop ENU
sa24435 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37811 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37812 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44076 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44077 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44078 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sdu7 Small Deletion Exon 1 Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fzd8a N/A 4
    MO2-fzd8a N/A 1
    TALEN1-fzd8a 2
    DISEASE ASSOCIATED WITH fzd8a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH fzd8a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process canonical Wnt signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function transmembrane signaling receptor activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fzd8a-201 (1)    Ensembl 2604
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fzd8a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:fzd8a-EGFP) hsp70l EGFPfzd8a Danio rerio 1 6
    MARKER RELATIONSHIPS
    fzd8a Contained in: [BAC] DKEY-18N12 (1) (order this)
    fzd8a Contains: [SNP] rs3729310 (1)
    fzd8a Encodes: [EST] fd02c05 (1)
    [cDNA] MGC:65761 (1), MGC:77586 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_130918 (1) 2628 nt
    Genomic GenBank:BX004842 (1) 193257 nt
    Select Tool
    Polypeptide UniProtKB:Q9PTT7 (1) 579 aa
    Sequence Information (all 24)
    ORTHOLOGY for fzd8a ( Chr: 24 )
    CITATIONS (58)