ZFIN ID: ZDB-GENE-000210-23
Gene Name: Meis homeobox 2b
Gene Symbol: meis2b    Nomenclature History

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Previous Names: meis2.1, meis2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have DNA binding activity. Involved in cardiac atrium morphogenesis and heart looping. Predicted to localize to nucleus. Is expressed in several structures, including anterior neural keel; heart rudiment; nervous system; neural plate; and pericardial region. Human ortholog(s) of this gene implicated in ceft palate, cardiac defects, and intellectual disabillity. Orthologous to human MEIS2 (Meis homeobox 2).
Genome Resources: Alliance (1),  Gene:30066 (1),  Ensembl(GRCz11):ENSDARG00000077840 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013767Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • nju55 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • nju62 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • s988 Indel Unknown Frameshift, Premature Stop TALEN
    sa23645 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-meis2b N/A 1
    MO2-meis2b N/A 1
    MO3-meis2b N/A 1
    MO4-meis2b N/A 1
    TALEN1-meis2b 1
    DISEASE ASSOCIATED WITH meis2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cleft palate, cardiac defects, and intellectual disabillity Alliance Cleft palate, cardiac defects, and mental retardation 600987
    DISEASE ASSOCIATED WITH meis2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cardiac atrium morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA meis2b-203 (1)    Ensembl 3104
    ncRNA meis2b-002 (1)    Ensembl 843
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM meis2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(meis2b:GAL4FF) meis2b GAL4FF Danio rerio 1 2
    MARKER RELATIONSHIPS
    meis2b Contained in: [BAC] CH73-277L12 (1), CH73-335N18 (1)
    meis2b Encodes: [cDNA] MGC:76815 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_130910 (1) 2838 nt
    Genomic GenBank:CU539064 (1) 102409 nt
    Select Tool
    Polypeptide UniProtKB:Q9PTM7 (1) 393 aa
    Sequence Information (all 17)
    ORTHOLOGY for meis2b ( Chr: 20 )
    CITATIONS (43)